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TL;DR
Short-term fasting in mice was shown to increase hepatic and neuronal autophagosome formation, while six-week alternate-day fasting reduced infarct area in a cardiac ischemia-reperfusion model.
Advances in Nutrition · 8 authors, 6 centres
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Short-term fasting in mice was shown to increase hepatic and neuronal autophagosome formation, while six-week alternate-day fasting reduced infarct area in a cardiac ischemia-reperfusion model.
Short-term fasting in mice was shown to increase hepatic and neuronal autophagosome formation, while six-week alternate-day fasting reduced infarct area in a cardiac ischemia-reperfusion model. Conversely, every-other-day feeding in 5XFAD mice promoted cortical neuroinflammatory responses and did not reduce plaque formation. The review notes that tissue sensitivity to fasting-induced autophagy varies and that excessive autophagic flux can overwhelm lysosomal degradation capacity, leading to cell death.