Rheumatology International · 5 authors, 3 centres
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This scoping review synthesized 32 studies to describe the wide-ranging physical, psychological, and social impacts of Ehlers-Danlos syndrome and hypermobility spectrum disorders in adults. The review found that gastrointestinal symptoms, mood disorders, and anxiety disorders are the most frequent manifestations, highlighting the need for multidisciplinary care.
This scoping review followed the Arksey and O'Malley framework to synthesize 32 studies on the biopsychosocial impact of Ehlers-Danlos syndrome and hypermobility spectrum disorders in adults. The review identified a wide range of impacts across physical systems (musculoskeletal, dermatological, gastrointestinal), psychological factors (mood and anxiety disorders), and social domains (education and employment). Gastroenterology, mood disorders, and anxiety disorders were the most frequently reported manifestations. The authors note that gastrointestinal symptoms are underdiagnosed and that psychiatric disorders are significantly more frequent in this population. A key limitation is that the review is restricted to the adult population, though symptoms may originate in childhood. The findings support a fragmented care system and call for a holistic, multidisciplinary approach to improve awareness and management.
