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TL;DR
This study found that the DREAM repressor complex limits DNA repair in somatic tissues; inactivating it in C. elegans, human cells, and progeroid mice enhanced DNA-repair gene expression and resistance to DNA damage.
Nature Structural & Molecular Biology · 7 authors, 3 centres
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This study found that the DREAM repressor complex limits DNA repair in somatic tissues; inactivating it in C. elegans, human cells, and progeroid mice enhanced DNA-repair gene expression and resistance to DNA damage.
The study used Caenorhabditis elegans, human cell lines, and progeroid Ercc1−/− mice to investigate the DREAM complex. Mutations or pharmacological inhibition of DREAM led to germline-like DNA-repair gene expression in somatic tissues. The authors propose DREAM acts as a conserved master repressor of DNA repair, and its inhibition could offer therapeutic avenues for DNA-repair deficiencies and age-related diseases.