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RCT·nutrition, clinical nutrition, geriatrics, internal medicine, cardiology·PMC10238773

The Effect of Crackers Enriched with Camelina Sativa Oil on Omega-3 Serum Fatty Acid Composition in Older Adults: A Randomized Placebo-Controlled Pilot Trial

The Journal of Nutrition, Health & Aging · 11 authors, 7 centres

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TL;DR

Participants consumed 35 g of enriched or placebo crackers twice daily for 12 weeks.

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Participants consumed 35 g of enriched or placebo crackers twice daily for 12 weeks. The central result was a significant increase in serum alpha-linolenic acid (ALA) concentration in the camelina group compared to placebo (p<0.01). Limitations include the small sample size and potential attrition bias from COVID-19 related dropouts. The study suggests Camelina oil is a promising plant-based source of ALA, but the clinical relevance of its effects on inflammation and lipids requires further investigation in larger trials.

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RCT

SPECIALTY

nutrition

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100% · A

ORIGINAL PAPER

PMC10238773

The Effect of Crackers Enriched with Camelina Sativa Oil on Omega-3 Serum Fatty Acid Composition in Older Adults: A Randomized Placebo-Controlled Pilot Trial

The Journal of Nutrition, Health & Aging

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ABSTRACT

Background Camelina sativa oil is one of the richest dietary sources of omega-3, with polyunsaturated fatty acids amounts of over 50%, linolenic acid content of around 40–45%, and linoleic acid of about 15%. Moreover, this oil is a valuable source of antioxidants which provide oxidative stability. All those features raise interest in considering Camelina oil as an alternative and sustainable oil source providing stable omega-3-rich emulsions for functional food production. Objectives The present study aimed to investigate the effects of Camelina oil-enriched crackers on serum omega-3 concentration, inflammatory markers and serum lipid profile. Design Randomized placebo-controlled pilot trial. Setting: Research and Development Center (Complife Italia s.r.l.). Participants Sixty-six free-living older volunteers (aged≥65 years). Intervention Older adults were enrolled and randomly assigned to one of two groups: the camelina group or the placebo group. Subjects consumed daily 35 g of crackers (Camelina enriched crackers or placebo ones) twice daily for 12 weeks. Measurements Serum polyunsaturated fatty acid profile, inflammatory status and serum lipid panel parameters were recorded pre and post-intervention. Results In the camelina group, alpha-linolenic acid serum concentration was significantly higher (p<0.01) compared to the placebo group at the end of the study. Concerning inflammatory plasma markers, a significant mean pro-inflammatory interleukin-18 plasma concentration decrease in the placebo group compared to the camelina one was observed (p<0.05). No significant differences in other mean inflammatory markers concentrations post-intervention were noted in either group. Lastly, examining the change in lipid profile, it is noteworthy that a higher reduction of total cholesterol, low-density lipoprotein and triglycerides in the camelina group postintervention, despite the lack of statistical significance. Conclusion Camelina oil significantly elevated the serum alpha-linolenic acid concentration with no significant changes in inflammatory markers and lipid profile. Electronic Supplementary Material Supplementary material is available for this article at 10.1007/s12603-023-1925-x and is accessible for authorized users.

CITATION EXPORT

R. De Giuseppe, I. Di Napoli, C. E. Tomasinelli et al.. The Effect of Crackers Enriched with Camelina Sativa Oil on Omega-3 Serum Fatty Acid Composition in Older Adults: A Randomized Placebo-Controlled Pilot Trial. The Journal of Nutrition, Health & Aging. (2023). https://doi.org/10.1007/s12603-023-1925-x

AUTHORS

11 · 7 CENTRES

R. De Giuseppe, I. Di Napoli, C. E. Tomasinelli, Alessandra Vincenti, G. Biino, E. Sommella, L. Ferron, P. Campiglia, F. Ferrara, P. M. Casali, H. Cena

1grid.8982.b0000 0004 1762 5736Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, via Bassi 21, 27100 Pavia, Italy
2grid.5326.20000 0001 1940 4177Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy
3grid.11780.3f0000 0004 1937 0335Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy
4FlaNat Research Italia Srl, Rho, Italy
5grid.418324.80000 0004 1781 8749Laboratory Medicine Department - Centro Diagnostico Italiano, Milan, Italy
6grid.8982.b0000 0004 1762 5736Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy
7Clinical nutrition Unit, General Medicine, ICS MAUGERI IRCCS, Pavia, Italy