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TL;DR
This prospective cohort study found that late-life depression (LLD) was associated with a lower disability-free survival in healthy older adults, meaning a shorter healthspan.
Acta psychiatrica Scandinavica · 16 authors, 11 centres
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This prospective cohort study found that late-life depression (LLD) was associated with a lower disability-free survival in healthy older adults, meaning a shorter healthspan.
A prospective cohort study analyzed data from 19,110 participants in the ASPREE study, who were followed for up to 7.3 years. Depressive symptoms were assessed using the CES-D-10, categorizing participants into LLD, subthreshold depression, or minimal/no symptoms. Disability-free survival was the primary outcome. Results showed LLD was associated with lower disability-free survival, with hazard ratios (HR) of 1.50 (95% CI, 1.23–1.82) in women and 1.30 (95% CI, 1.03–1.64) in men after adjustments. Subthreshold depression was also associated with lower disability-free survival in both sexes. The study had a large sample and prospective design but used a screening tool for depression, not a clinical diagnosis, and followed a healthy cohort, which may limit generalizability. Findings suggest late-life depression may be an important risk factor for shortened healthspan.