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other·preclinical research, immunology, nutrition, biomedical research·PMC10537032

The Effect of Moderate-Intensity Physical Exercise on Some Serum Inflammation Markers and the Immune System in Rats Fed Intermittent Fasting with a High-Fat Diet

Medicina · 6 authors, 3 centres

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TL;DR

Additionally, B lymphocyte and monocyte levels were higher in the combined HFD, intermittent fasting, and exercise group.

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Additionally, B lymphocyte and monocyte levels were higher in the combined HFD, intermittent fasting, and exercise group. TNF-α, a pro-inflammatory cytokine, was highest in the HFD-only group, while IL-10, an anti-inflammatory cytokine, was highest in the combined intervention group.

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other

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preclinical research

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ORIGINAL PAPER

PMC10537032

The Effect of Moderate-Intensity Physical Exercise on Some Serum Inflammation Markers and the Immune System in Rats Fed Intermittent Fasting with a High-Fat Diet

Medicina

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ABSTRACT

Background and Objectives : This study aimed to investigate the impact of moderate-intensity physical exercise on serum inflammation markers and the immune system in rats that were fed a high-fat diet (HFD) with intermittent fasting. Materials and Methods : A total of 48 Wistar albino male rats were included in the study and divided into eight groups, each consisting of six rats. Group 1 served as the control group (CG), receiving a standard diet. Group 2 followed the standard nutrition program with intermittent fasting (CG + IF). Group 3 underwent exercise with a standard diet (CG + E). Group 4 underwent both a standard diet with intermittent fasting and exercise (CG + IF + E). Group 5 was fed a high-fat diet (HFD). Group 6 received a high-fat diet with intermittent fasting (HFD + IF). Group 7 followed a high-fat diet with exercise (HFD + E). Group 8 underwent both a high-fat diet with intermittent fasting and exercise (HFD + IF + E). The study lasted for 8 weeks. Results : The results of the analysis show that lymphocyte cell levels in groups HFD + IF, HFD + IF, and HFD + IF + E were higher compared to groups CG-HFD ( p < 0.05). Additionally, B lymphocyte and monocyte cell levels were higher in group HFD + IF + E compared to groups CG, CG + IF, and CG + IF + E, as well as CG, CG + IF, and CG + E, respectively. TNF-α levels were significantly higher in group HFD compared to the other groups. Furthermore, IL 10 levels were higher in group HFD + IF + E compared to the other groups. Conclusions : These findings indicate that moderate exercise and intermittent fasting, particularly in groups fed a high-fat diet, increased anti-inflammatory cytokine levels, and certain immune system cell counts, while decreasing pro-inflammatory cytokine levels.

CITATION EXPORT

Nizamettin Günbatar, Bahattin Bulduk, Selver Bezgin et al.. The Effect of Moderate-Intensity Physical Exercise on Some Serum Inflammation Markers and the Immune System in Rats Fed Intermittent Fasting with a High-Fat Diet. Medicina. (2023). https://doi.org/10.3390/medicina59091687

AUTHORS

6 · 3 CENTRES

Nizamettin Günbatar, Bahattin Bulduk, Selver Bezgin, Gökhan Oto, Fahri Bayıroğlu, Mehmet Bulduk

1Van School of Health, Van YuzuncuYıl University, 65090 Van, Turkey; [email protected] (B.B.); [email protected] (S.B.); [email protected] (M.B.)
2Department of Pharmacology, Van YuzuncuYıl University, 65090 Van, Turkey; [email protected]
3Faculty of Medicine, Department of Physiology, Yıldırım Beyazıt University, 06200 Ankara, Turkey; [email protected]

EDITOR / REVIEWER

Martin Burtscher