Pharmaceutics · 12 authors, 7 centres
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This prospective observational study of 46 patients with neovascular age-related macular degeneration (AMD) found that women and patients on statin treatment had a worse short-term response to intravitreal ranibizumab, while higher baseline uric acid was associated with a better response.
This prospective observational cohort study enrolled 46 treatment-naive patients with neovascular AMD. They received three monthly intravitreal ranibizumab injections, with clinical, biochemical, and inflammatory assessments at baseline and one month post-third injection. The central results indicated that women and patients on statin treatment were prognostic factors for worse short-term response. Higher baseline uric acid (over 1 point difference) was significantly associated with good response (p = 0.007). Cholesterol and white blood cell count decreased significantly over time during treatment. The study had a primary limitation of a small sample size due to strict inclusion criteria and single-center recruitment. The findings suggest baseline uric acid may help predict non-response, while cholesterol and white blood cell changes may monitor response, but further larger studies are needed to establish causality.
