SEARCHNARRATIVE_REVIEWinfectious disease, pulmonology

narrative_review·infectious disease, pulmonology, critical care, immunology, nutrition·PMC10439304

The Effects of Anti-platelets and Micronutrients in the Recovery of COVID-19 Patients: A Review

Cureus · 2 authors, 1 centre

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TL;DR

It synthesizes findings from randomized controlled trials and observational cohorts.

Full summary

772 CHARS

It synthesizes findings from randomized controlled trials and observational cohorts. Key results indicate that aspirin use in hospitalized patients is associated with a reduction in 28-day mortality (e.g., OR 0.85). Evidence for micronutrients is inconsistent: high-dose vitamin C did not reduce mortality but improved some inflammatory markers; a single high-dose vitamin D3 supplement did not improve outcomes for hospitalized patients, though a separate trial suggested it might prevent infection in exposed healthcare workers; and zinc supplementation did not significantly alter symptom duration. It concludes that while certain interventions show promise, further validation is needed, and an imbalance in nutrition can compromise immune function in severe COVID-19.

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narrative_review

SPECIALTY

infectious disease

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AI pipeline

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100% · A

ORIGINAL PAPER

PMC10439304

The Effects of Anti-platelets and Micronutrients in the Recovery of COVID-19 Patients: A Review

Cureus

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ABSTRACT

Abstract COVID-19 or coronavirus disease is a pneumonia-like condition caused by the SARS-CoV2 virus. Many mutations of this virus have emerged throughout the two-year period of this pandemic. However, clinical presentations, diagnostic methods, and treatment of COVID-19 remain relatively unchanged. Various substances have been assessed for their functions as COVID-19 immunomodulators. Said substances in this article include aspirin, vitamin C, vitamin D3, zinc, and selenium. Aspirin was found to reduce mortality risk and embolism events. Vitamin C did not seem to improve mechanical ventilation-free days but did improve oxygenation (PaO2/FiO2), peripheral capillary oxygen saturation (SpO2), and body temperature in severe COVID-19 patients. Vitamin D3 was not significantly different compared to placebo in improving mortality in hospitalized patients. However, respiratory tract infection (COVID-19 included) events were lower in individuals given vitamin D3 compared to those who were not. Zinc combined with ascorbic acid caused a quick reduction in symptoms but was not significant compared to zinc alone, ascorbic acid alone, or standard care. Individuals with lower levels of selenium were found to have worse outcomes of COVID-19 compared to those with high levels of selenium. However, further studies, especially clinical trials, are needed. Asprinol is a drug that contains vitamins and minerals plus aspirin which are suggested to help alleviate symptoms and improve outcomes of COVID-19. This review aims to assess the efficacy of asprinol contents in COVID-19 patients. Keywords: recovery, asprinol, aspirin, micronutrients, covid-19

CITATION EXPORT

Gurmeet Singh, Nova Fauzi. The Effects of Anti-platelets and Micronutrients in the Recovery of COVID-19 Patients: A Review. Cureus. (2023). https://doi.org/10.7759/cureus.42164

AUTHORS

2 · 1 CENTRES

Gurmeet Singh, Nova Fauzi

1 Internal Medicine, Respirology, and Critical Illness, Universitas Indonesia, Jakarta, IDN