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TL;DR
Studies were categorized by whether omega-3 PUFA supplementation was combined with conventional antitumor treatments or used alone as prevention/treatment.
Nutrients · 11 authors, 2 centres
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Studies were categorized by whether omega-3 PUFA supplementation was combined with conventional antitumor treatments or used alone as prevention/treatment.
Studies were categorized by whether omega-3 PUFA supplementation was combined with conventional antitumor treatments or used alone as prevention/treatment. The review found a consistent tendency for omega-3 PUFAs combined with drugs to decrease tumor weight and size, particularly in early stages, and to reduce metastasis more effectively than drugs alone. When used alone for prevention, omega-3 PUFA-enriched diets were associated with a reduced tumor incidence. The analysis noted great heterogeneity in experimental designs, including different omega-3 sources, types, doses, and animal ages, making it difficult to determine optimal dosing. The review also highlighted that younger animals showed a stronger protective effect from omega-3 PUFAs.