Current Obesity Reports · 11 authors, 11 centres
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This narrative review summarizes evidence that obesity is an independent risk factor for chronic kidney disease (CKD) progression. It concludes that weight loss through various strategies can slow kidney damage and improve proteinuria and glomerular filtration rate (GFR).
This narrative review examines the role of obesity in the development and progression of chronic kidney disease (CKD) and summarizes management strategies for patients with both conditions. The authors describe that obesity can directly and indirectly harm the kidney, leading to glomerular hyperfiltration, proteinuria, and reduced GFR. The review discusses evidence supporting lifestyle modification, anti-obesity drugs, and bariatric surgery as weight loss methods. It states that weight loss can slow CKD progression by reducing proteinuria and improving GFR, with bariatric surgery noted to prevent the decline in renal function. A key limitation highlighted is the current lack of clinical practice guidelines for managing obesity in CKD.
