Microorganisms · 11 authors, 13 centres
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This cross-sectional study compared the gut microbiome of an Indigenous Colombian Wiwa population to an urban control group using 16S rRNA gene sequencing. The key result was a distinct, dysbiotic microbiome composition in the Indigenous population, with specific bacterial genera statistically associated with high rates of gastrointestinal infections like E. coli and helminths.
This cross-sectional study used 16S rRNA gene amplicon sequencing to analyze the gut microbiome of 126 stool samples from the Indigenous Wiwa population and 9 from a local urban Colombian population. The central finding was that the microbiome composition was distinct between groups, with locational, age, and gender-specific differences. Alpha- and beta-diversity analysis separated the urban site from the two Indigenous villages. Urban microbiomes were dominated by Bacteriodetes, while Indigenous samples had a four times higher abundance of Proteobacteria. Associations were identified between specific bacterial genera and enteric pathogens: Sutterella with EHEC; Faecalibacteria with EPEC and helminths; and Parabacteroides, Prevotella, and Butyrivibrio with salmonellosis, EPEC, and helminths. Dialister was associated with gastrointestinal symptoms.
