SEARCHCOHORTneurology, geriatrics

cohort·neurology, geriatrics, epidemiology, public health, observational study·PMC10610524

The Healthy Brain Initiative (HBI): A prospective cohort study protocol

PLOS ONE · 9 authors, 2 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

This paper outlines the protocol for the Healthy Brain Initiative, a longitudinal cohort study following 500 diverse older adults to study risk and resilience factors for Alzheimer’s disease and related dementias through deep phenotyping, biomarkers, and neuroimaging.

Full summary

725 CHARS

The Healthy Brain Initiative (HBI) is a longitudinal, observational cohort study designed to follow 500 racially/ethnically diverse older adults (≥50 years) without dementia in South Florida. The protocol details methods for annual deep phenotyping, including clinical, cognitive, behavioral, genetic, and neuroimaging data collection, as well as biospecimens. A primary goal is to characterize Alzheimer’s disease and related dementias (ADRD) risk and resilience using a Brain Health Platform and the ATN framework. The study will develop a data repository to identify modifiable factors and novel biomarkers. Limitations noted include potential lack of generalizability due to recruitment biases common in research cohorts.

STUDY TYPE

cohort

SPECIALTY

neurology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10610524

The Healthy Brain Initiative (HBI): A prospective cohort study protocol

PLOS ONE

READ THE FULL PAPER

ABSTRACT

Background The Health Brain Initiative (HBI), established by University of Miami’s Comprehensive Center for Brain Health (CCBH), follows racially/ethnically diverse older adults without dementia living in South Florida. With dementia prevention and brain health promotion as an overarching goal, HBI will advance scientific knowledge by developing novel assessments and non-invasive biomarkers of Alzheimer’s disease and related dementias (ADRD), examining additive effects of sociodemographic, lifestyle, neurological and biobehavioral measures, and employing innovative, methodologically advanced modeling methods to characterize ADRD risk and resilience factors and transition of brain aging. Methods HBI is a longitudinal, observational cohort study that will follow 500 deeply-phenotyped participants annually to collect, analyze, and store clinical, cognitive, behavioral, functional, genetic, and neuroimaging data and biospecimens. Participants are ≥50 years old; have no, subjective, or mild cognitive impairment; have a study partner; and are eligible to undergo magnetic resonance imaging (MRI). Recruitment is community-based including advertisements, word-of-mouth, community events, and physician referrals. At baseline, following informed consent, participants complete detailed web-based surveys (e.g., demographics, health history, risk and resilience factors), followed by two half-day visits which include neurological exams, cognitive and functional assessments, an overnight sleep study, and biospecimen collection. Structural and functional MRI is completed by all participants and a subset also consent to amyloid PET imaging. Annual follow-up visits repeat the same data and biospecimen collection as baseline, except that MRIs are conducted every other year after baseline. Ethics and expected impact HBI has been approved by the University of Miami Miller School of Medicine Institutional Review Board. Participants provide informed consent at baseline and are re-consented as needed with protocol changes. Data collected by HBI will lead to breakthroughs in developing new diagnostics and therapeutics, creating comprehensive diagnostic evaluations, and providing the evidence base for precision medicine approaches to dementia prevention with individualized treatment plans.

CITATION EXPORT

Lilah M. Besser, Stephanie Chrisphonte, Michael J. Kleiman et al.. The Healthy Brain Initiative (HBI): A prospective cohort study protocol. PLOS ONE. (2023). https://doi.org/10.1371/journal.pone.0293634

AUTHORS

9 · 2 CENTRES

Lilah M. Besser, Stephanie Chrisphonte, Michael J. Kleiman, Deirdre O’Shea, Amie Rosenfeld, Magdalena Tolea, James E. Galvin, Avanti Dey, Avanti Dey

Department of Neurology, Comprehensive Center for Brain Health, University of Miami Miller School of Medicine, Boca Raton, Florida, United States of America
Public Library of Science, UNITED STATES

EDITOR / REVIEWER

Avanti Dey