SEARCHNARRATIVE_REVIEWrheumatology, gastroenterology

narrative_review·rheumatology, gastroenterology, immunology, preclinical research, biomedical research·PMC10606932

The Human Microbiome and Its Role in Musculoskeletal Disorders

Genes · 12 authors, 6 centres

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The authors describe the composition and variability of the human microbiota and discuss how lifestyle changes over the last 100 years have altered gut microbial populations, which may be associated with variations in disease prevalence. The primary limitation is that this is a broad narrative review that summarizes existing associations and hypotheses without presenting original clinical or preclinical data, and it does not establish causation.

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narrative_review

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rheumatology

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ORIGINAL PAPER

PMC10606932

The Human Microbiome and Its Role in Musculoskeletal Disorders

Genes

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ABSTRACT

Abstract Musculoskeletal diseases (MSDs) are characterized as injuries and illnesses that affect the musculoskeletal system. MSDs affect every population worldwide and are associated with substantial global burden. Variations in the makeup of the gut microbiota may be related to chronic MSDs. There is growing interest in exploring potential connections between chronic MSDs and variations in the composition of gut microbiota. The human microbiota is a complex community consisting of viruses, archaea, bacteria, and eukaryotes, both inside and outside of the human body. These microorganisms play crucial roles in influencing human physiology, impacting metabolic and immunological systems in health and disease. Different body areas host specific types of microorganisms, with facultative anaerobes dominating the gastrointestinal tract (able to thrive with or without oxygen), while strict aerobes prevail in the nasal cavity, respiratory tract, and skin surfaces (requiring oxygen for development). Together with the immune system, these bacteria have coevolved throughout time, forming complex biological relationships. Changes in the microbial ecology of the gut may have a big impact on health and can help illnesses develop. These changes are frequently impacted by lifestyle choices and underlying medical disorders. The potential for safety, expenses, and efficacy of microbiota-based medicines, even with occasional delivery, has attracted interest. They are, therefore, a desirable candidate for treating MSDs that are chronic and that may have variable progression patterns. As such, the following is a narrative review to address the role of the human microbiome as it relates to MSDs. Keywords: microbiome, musculoskeletal, gastrointestinal, therapeutics, immune system, disc degeneration, pain

CITATION EXPORT

Khaled Aboushaala, Arnold Y L Wong, Juan Nicolas Barajas et al.. The Human Microbiome and Its Role in Musculoskeletal Disorders. Genes. (2023). https://doi.org/10.3390/genes14101937

AUTHORS

12 · 6 CENTRES

Khaled Aboushaala, Arnold Y L Wong, Juan Nicolas Barajas, Perry Lim, Lena Al-Harthi, Ana Chee, Christopher B Forsyth, Chun-do Oh, Sheila J Toro, Frances M K Williams, Howard S An, Dino Samartzis

1Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA; [email protected] (K.A.); [email protected] (J.N.B.); [email protected] (P.L.); [email protected] (A.C.); [email protected] (C.-d.O.); [email protected] (S.J.T.); [email protected] (H.S.A.)
2International Spine Research and Innovation Initiative, Rush University Medical Center, Chicago, IL 60612, USA
3Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China; [email protected]
4Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL 60612, USA; [email protected]
5Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA; [email protected]
6Department of Twin Research, King’s College London, London WC2R 2LS, UK; [email protected]