Metabolites · 2 authors, 5 centres
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This narrative review synthesizes evidence that maternal nutritional and metabolic disturbances during pregnancy can lead to fetal programming and increased risk of hypertension in offspring. It proposes that targeting nutrient-sensing signals and reducing metabolic wastes may offer future prevention strategies.
This narrative review discusses how maternal dietary nutrient intake and metabolic waste accumulation during pregnancy can disturb nutrient-sensing pathways, leading to fetal programming and an increased risk of hypertension in offspring. The authors synthesize evidence from both human and animal studies to highlight causal mechanisms linking maternal metabolic disturbances to altered fetal development. The review summarizes current knowledge on nutrient-sensing signals (for sugars, amino acids, lipids, energy) and metabolites as potential targets for drug discovery. Key implications are that novel early-life interventions, such as nutritional strategies or targeting nutrient-sensing signals, could help prevent hypertension. A major limitation noted is the gap between animal research and human application, and the need for longitudinal human studies to understand the timing of metabolic disturbances.
