SEARCHNARRATIVE_REVIEWnutrition, gastroenterology

narrative_review·nutrition, gastroenterology, preclinical research, internal medicine, neurology·PMC10224471

The Impact of Nutrition, Physical Activity, Beneficial Microbes, and Fecal Microbiota Transplant for Improving Health

Life · 3 authors, 4 centres

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TL;DR

It also proposes a pilot clinical trial design for phenylketonuria patients combining probiotics and exercise.

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A pilot clinical trial design is proposed for phenylketonuria (PKU) patients combining probiotics and exercise, using omics technology to assess neuroactive biogenic amines and specific microbial abundance changes as outcomes. The authors conclude that aligning specific microbes with targeted dietary intake warrants further human interventional research.

STUDY TYPE

narrative_review

SPECIALTY

nutrition

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AI pipeline

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100% · A

ORIGINAL PAPER

PMC10224471

The Impact of Nutrition, Physical Activity, Beneficial Microbes, and Fecal Microbiota Transplant for Improving Health

Life

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ABSTRACT

The recognition that microbes are integral to human life has led to studies on how to manipulate them in favor of health outcomes. To date, there has been no conjoint recommendation for the intake of dietary compounds that can complement the ingested organisms in terms of promoting an improved health outcome. The aim of this review is to discuss how beneficial microbes in the form of probiotics, fermented foods, and donor feces are being used to manage health. In addition, we explore the rationale for selecting beneficial microbial strains and aligning diets to accommodate their propagation in the gut. A pilot clinical trial design is presented to examine the effects of probiotics and exercise in patients with phenylketonuria (PKU); it is the most common inborn error of amino acid metabolism, and it is a complication that requires lifelong dietary intervention. The example design is provided to illustrate the importance of using omics technology to see if the intervention elevates neuroactive biogenic amines in the plasma; increases the abundance of Eubacterium rectale, Coprococcus eutactus, Akkermansia muciniphila , or Butyricicoccus ; and increases Escherichia/Shigella in the gut, all as markers of improved health. By emphasizing the combined importance of diet, microbial supplements, and the gut microbiome, we hope that future studies will better align these components, not only to improve outcomes, but also to enhance our understanding of the mechanisms.

CITATION EXPORT

Justine Keathley, Jessica White, Gregor Reid. The Impact of Nutrition, Physical Activity, Beneficial Microbes, and Fecal Microbiota Transplant for Improving Health. Life. (2023). https://doi.org/10.3390/life13051124

AUTHORS

3 · 4 CENTRES

Justine Keathley, Jessica White, Gregor Reid

1Department of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Road East, Guelph, ON N1G 2W1, Canada; [email protected]
2Department of Food and Nutritional Sciences, Brescia College, 1285 Western Road, London, ON N6G 1H2, Canada
3Departments of Microbiology & Immunology and Surgery, The University of Western Ontario, London, ON N6A 3K7, Canada
4Lawson Health Research Institute, 268 Grosvenor Street, London, ON N6A 4V2, Canada

EDITOR / REVIEWER

Fen Zhang, Kun Li, Tao Zuo, Qinglong Wu