SEARCHCASE-CONTROLobstetrics and gynecology, endocrinology

case-control·obstetrics and gynecology, endocrinology, nutrition, micronutrients, vitamins·PMC10062660

The impact of vitamin D deficiency on some biochemical parameters and clinical outcome in Palestinian pregnant women during the first trimester

PLOS ONE · 7 authors, 4 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

Full summary

400 CHARS

This case-control study compared 100 first-trimester pregnant women with 100 non-pregnant women in Gaza to examine the relationship between vitamin D status and thyroid and parathyroid hormone levels. Anti-TPO and anti-TG were also significantly lower in the pregnant group (P<0.001). The findings suggest an association between vitamin D deficiency and altered thyroid parameters in early pregnancy.

STUDY TYPE

case-control

SPECIALTY

obstetrics and gynecology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10062660

The impact of vitamin D deficiency on some biochemical parameters and clinical outcome in Palestinian pregnant women during the first trimester

PLOS ONE

READ THE FULL PAPER

ABSTRACT

Abstract Background and aim Vitamin D deficiency is widespread worldwide and associated with negative effects on maternal and neonatal health. This study aimed to evaluate the relationship between vitamin D and thyroid and parathyroid hormone levels in the first trimester of pregnancy. Material and methods This case control study included 200 participants aged (18–40) years divided into two groups; 100 pregnant females at the first trimester as case group, attending the main general clinical centers in Gaza strip, Palestine and 100 apparently healthy non-pregnant females as control group. Vitamin D, free thyroxine, free triiodothyronine, thyroid stimulating hormone, parathyroid, and the autoantibodies specific for thyroglobulin and thyroid peroxidase in serum were measured in all mothers and statistically analyzed using SPSS version 21 software. Results Serum vitamin D, TSH, anti-TPO, and anti-TG levels were significantly decrease while, parathyroid levels were non-significantly decreased in the first trimester of pregnancy compered to control group. The levels of fT 4 were significantly increased and level of fT 3 were non significantly increased among pregnant mothers compered to control group. Analyses using Pearson correlation coefficients showed positive correlations between vitamin D with fT 4 , fT 3 , Anti-TPO with P -value < 0.05 and negative correlations with mother age, TSH, PTH with P -value < 0.05 in early pregnancy. Conclusions Vitamin D deficiency among pregnant women in the first-trimester can be associated with thyroid, parathyroid parameters and thyroid autoantibodies with potential adverse consequences for overall health, emphasizing a routine monitoring and vitamin D supplementation prevention strategies to optimize maternal and fetal outcomes.

CITATION EXPORT

Saleh Nazmy Mwafy, Safaa Ramadan Abed El- Nabi, Mohammed Marwan Laqqan et al.. The impact of vitamin D deficiency on some biochemical parameters and clinical outcome in Palestinian pregnant women during the first trimester. PLOS ONE. (2023). https://doi.org/10.1371/journal.pone.0283392

AUTHORS

7 · 4 CENTRES

Saleh Nazmy Mwafy, Safaa Ramadan Abed El- Nabi, Mohammed Marwan Laqqan, Maged Mohamed Yassin, Kornelia Zaręba, Kornelia Zaręba, Kornelia Zaręba

1Department of Biology, Faculty of Science, Al Azhar University-Gaza, Gaza Strip, Palestine
2Faculty of Health Sciences, Department of Laboratory Medical Sciences, Islamic University of Gaza, Gaza, Palestine
3Faculty of Medicine, Islamic University of Gaza, Gaza, Palestine
4United Arab Emirates University, UNITED ARAB EMIRATES