Nutrients · 6 authors, 4 centres
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This preclinical rat study investigated how dietary fibers (pectin, inulin, psyllium) modulate the effects of copper nanoparticles on cardiovascular health. The central result was that specific fibers, particularly pectin, inulin, and psyllium, altered antioxidant mechanisms and vasodilation responses in the context of copper nanoparticle exposure.
Male Wistar Han rats (n not reported) were fed a control diet (8% cellulose) or one of three experimental diets where 6% cellulose was replaced with pectin, inulin, or psyllium. Each diet was given with either a standard (6.5 mg/kg) or double (13 mg/kg) dose of copper nanoparticles for 6 weeks. Cardiovascular effects were studied using isolated rat hearts and thoracic arteries. The results showed that replacing ionic copper with copper nanoparticles reduced plasma lipid-soluble antioxidant capacity and increased heart hydrogen peroxide decomposition, but did not affect aortic ring vasodilation or heart superoxide dismutation. Doubling the copper nanoparticle dose had no negative effect. The fibers had distinct effects: inulin and psyllium most visibly affected antioxidant mechanisms and vasodilation, while pectin most strongly inhibited prostanoid production from cyclooxygenase-2 in aortic rings.
