SEARCHNARRATIVE_REVIEWretina, ophthalmology

narrative_review·retina, ophthalmology, preclinical research, neurology·PMC10889697

The Interplay between Neurotransmitters and Calcium Dynamics in Retinal Synapses during Development, Health, and Disease

International Journal of Molecular Sciences · 6 authors, 5 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

This narrative review summarizes the known mechanisms of how key neurotransmitters interact with calcium signaling in the retina across development and disease. It identifies significant knowledge gaps in understanding these complex interactions, which could inform future therapeutic strategies for retinal disorders.

Full summary

668 CHARS

This narrative review synthesizes existing knowledge on the roles of glutamate, GABA, glycine, dopamine, and acetylcholine and their interplay with calcium dynamics in the vertebrate retina. The authors describe how these neurotransmitters orchestrate cellular processes critical for retinal development and healthy physiological function. The review highlights that while individual neurotransmitter roles have been studied, the holistic integration of their interactions with calcium signaling remains poorly understood. The authors conclude that addressing these gaps is crucial for advancing basic understanding and developing novel therapies for retinal diseases.

STUDY TYPE

narrative_review

SPECIALTY

retina

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10889697

The Interplay between Neurotransmitters and Calcium Dynamics in Retinal Synapses during Development, Health, and Disease

International Journal of Molecular Sciences

READ THE FULL PAPER

ABSTRACT

The intricate functionality of the vertebrate retina relies on the interplay between neurotransmitter activity and calcium (Ca 2+ ) dynamics, offering important insights into developmental processes, physiological functioning, and disease progression. Neurotransmitters orchestrate cellular processes to shape the behavior of the retina under diverse circumstances. Despite research to elucidate the roles of individual neurotransmitters in the visual system, there remains a gap in our understanding of the holistic integration of their interplay with Ca 2+ dynamics in the broader context of neuronal development, health, and disease. To address this gap, the present review explores the mechanisms used by the neurotransmitters glutamate, gamma-aminobutyric acid (GABA), glycine, dopamine, and acetylcholine (ACh) and their interplay with Ca 2+ dynamics. This conceptual outline is intended to inform and guide future research, underpinning novel therapeutic avenues for retinal-associated disorders.

CITATION EXPORT

Johane M. Boff, Abhishek P. Shrestha, Saivikram Madireddy et al.. The Interplay between Neurotransmitters and Calcium Dynamics in Retinal Synapses during Development, Health, and Disease. International Journal of Molecular Sciences. (2024). https://doi.org/10.3390/ijms25042226

AUTHORS

6 · 5 CENTRES

Johane M. Boff, Abhishek P. Shrestha, Saivikram Madireddy, Nilmini Viswaprakash, Luca Della Santina, Thirumalini Vaithianathan

1Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA; [email protected] (J.M.B.); [email protected] (A.P.S.)
2College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA; [email protected]
3Department of Medical Education, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA; [email protected]
4College of Optometry, University of Houston, Houston, TX 77204, USA
5Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA

EDITOR / REVIEWER

Antonio Pisani