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TL;DR
Key limitations of current models are discussed, such as variable spheroid size, nutrient distribution issues, expense, difficulty in achieving in vivo maturity, and challenges with fabrication and analysis.
Stem Cell Research & Therapy · 7 authors, 3 centres
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Key limitations of current models are discussed, such as variable spheroid size, nutrient distribution issues, expense, difficulty in achieving in vivo maturity, and challenges with fabrication and analysis.
Key limitations of current models are discussed, such as variable spheroid size, nutrient distribution issues, expense, difficulty in achieving in vivo maturity, and challenges with fabrication and analysis. The review emphasizes that unresolved technical hurdles, including inadequate vascularization, core necrosis, and the need for scaffold optimization, prevent the full application of these models. Implications suggest that integrating vascular cells and developing composite scaffolds could improve their utility for drug discovery and studying long-term effects like post-acute sequelae of COVID-19.