Molecular Biomedicine · 17 authors, 2 centres
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This is a narrative review that summarizes the molecular mechanisms of ferroptosis, a form of iron-dependent cell death, and discusses its established or potential roles in various diseases, including cancer, neurodegeneration, and organ injury.
This narrative review synthesizes existing preclinical and mechanistic literature on ferroptosis, defined as regulated cell death driven by iron-dependent lipid peroxidation. The review describes ferroptosis as distinct from apoptosis, necrosis, and autophagy, and links it to metabolic pathways involving glutathione, phospholipids, and CoQ10. It discusses the role of ferroptosis in pathological cell death for degenerative diseases, cancer, stroke, and acute kidney injury, noting its potential as both a disease mechanism and a therapeutic target. The central conclusion is that while compounds exist to modulate ferroptosis, few are in clinical application, and developing effective strategies is a key challenge. The review has significant limitations: it does not present original data and relies on the synthesis of previously published studies.
