SEARCHCOHORTepidemiology, nutrition

cohort·epidemiology, nutrition, endocrinology, public health, observational study·PMC10475125

The mediating role of obesity on the prospective association between urinary sucrose and diabetes incidence in a sub-cohort of the EPIC-Norfolk

Nutrition & Diabetes · 5 authors, 5 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

This prospective cohort study compared objective urinary sucrose and self-reported sucrose intake for predicting diabetes. While self-reported intake suggested a lower risk, urinary sucrose showed a positive association with incident diabetes, with body mass index partly mediating this link.

Full summary

501 CHARS

This study analyzed a sub-cohort of 2996 participants from the EPIC-Norfolk prospective cohort to investigate associations between sucrose intake, measured by self-report (FFQ and 7-day diet diaries) and urinary sucrose, with incident diabetes over a mean follow-up of 11.2 years. Cox proportional hazard models were used. The findings suggest that an objective biomarker may point to a positive association, in contrast to some self-report data, and highlight the potential mediating role of obesity.

STUDY TYPE

cohort

SPECIALTY

epidemiology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10475125

The mediating role of obesity on the prospective association between urinary sucrose and diabetes incidence in a sub-cohort of the EPIC-Norfolk

Nutrition & Diabetes

READ THE FULL PAPER

ABSTRACT

Abstract Background/objectives Findings from epidemiological studies showed controversial findings between dietary sugar intake and the development of diabetes. Most of these studies assessed dietary sugar intake by self-reports which might be prone to bias. Urinary sucrose, an objective biomarker of sucrose intake, might provide better insights into this association. Thus, the aim of this study was to investigate the associations between sucrose intake, measured via self-reports and urinary sucrose, with incident diabetes and to detect the impact of obesity on this association. Subjects/methods Data of a sub-group ( n = 2996) from the prospective EPIC-Norfolk cohort were investigated. Sucrose intake was assessed by self-reports (validated food frequency questionnaire (FFQ) and 7-day diet diaries (7DD)) and as an objective urinary sucrose biomarker. Cox proportional hazard models were conducted to calculate hazard ratios (HRs) and 95% confidence intervals (CI) for the associations between urinary and dietary sucrose intake and incident diabetes. Mediation analysis was performed to investigate the mediated percentage of body mass index (BMI) and waist circumference (WC) on this association. Results The mean age of the participants was 60.6 ± 9.5 years and 53% were women. After a mean follow-up of 11.2 ± 2.9 years, 97 participants developed diabetes. Findings suggested inverse associations regarding incident diabetes for self-reported sucrose intake per 50 g/d via 7DD [HR: 0.63 (95% CI: 0.43, 0.91)], and a tendency via FFQ [HR: 0.81 (95% CI: 0.46, 1.42)]. Urinary sucrose indicated a positive association with incident diabetes for each increase of 100 µM [HR: 1.14 (95% CI: 0.95, 1.36)]. The proportion mediated of BMI and WC for this association was 16 and 22%. Conclusions These findings indicate that sucrose measured as objective urinary biomarker points to a positive association with incident diabetes. BMI might partly mediate this association. However, to obtain more precise results, more studies are warranted that consider this objective biomarker. Subject terms: Risk factors, Type 2 diabetes

CITATION EXPORT

Alexander Lang, Oliver Kuss, Tim Filla et al.. The mediating role of obesity on the prospective association between urinary sucrose and diabetes incidence in a sub-cohort of the EPIC-Norfolk. Nutrition & Diabetes. (2023). https://doi.org/10.1038/s41387-023-00243-5

AUTHORS

5 · 5 CENTRES

Alexander Lang, Oliver Kuss, Tim Filla, Gunter Kuhnle, Sabrina Schlesinger

1Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Auf’m Hennekamp 65, D-40225 Düsseldorf, Germany
2Centre for Health and Society, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany Institute for Biometrics and Bioinformatics, University Hospital, Düsseldorf, Germany
3German Center for Diabetes Research, Partner Düsseldorf, München-Neuherberg, Germany
4Department of Rheumatology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
5Department of Food & Nutritional Sciences, University of Reading, Reading, RG6 6DZ United Kingdom