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RCT·nutrition, clinical nutrition, endocrinology, micronutrients, antioxidants·PMC10030435

The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study

European Journal of Nutrition · 5 authors, 3 centres

AI SUMMARY

FIDELITY 100%

POPULATIONEight healthy males (22.4 ± 3.3 years, BMI: 25.7 ± 2.4 kg.m²)

INTERVENTIONAcute ingestion of 1450 mg of epigallocatechin gallate (EGCG)

COMPARISONPlacebo (PLAC)

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

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TL;DR

This randomized, placebo-controlled cross-over study in eight healthy males found that acute ingestion of the green tea polyphenol EGCG (1450 mg) significantly reduced circulating adrenaline and noradrenaline levels during graded exercise to exhaustion, but also led to a lower peak rate of lipid oxidation.

Full summary

915 CHARS

This study investigated the effect of a single high dose of EGCG on catecholamine metabolism during incremental cycling exercise. Eight males completed two trials (EGCG and placebo) in a randomized, blinded, cross-over design. Blood samples were analyzed at rest, post-ingestion, and at key exercise thresholds. The central finding was that EGCG significantly lowered plasma adrenaline at FATpeak (P < 0.05), lactate threshold (P < 0.001), and VO2peak (P < 0.01), and lowered noradrenaline at multiple points (P < 0.05 to P < 0.01) compared to placebo. A novel secondary finding was a 32% reduction in peak lipid oxidation rate with EGCG (0.33 vs. 0.49 g.min⁻¹, P < 0.05). Performance (time to exhaustion) and other metabolic markers (metanephrines, lactate, glucose) were similar between trials. The authors suggest lower catecholamines may explain reduced lipid oxidation, but the exact mechanism remains unclear.

PICO

PPOPULATION

Eight healthy males (22.4 ± 3.3 years, BMI: 25.7 ± 2.4 kg.m²)

IINTERVENTION

Acute ingestion of 1450 mg of epigallocatechin gallate (EGCG)

OOUTCOME

Circulating catecholamine (adrenaline, noradrenaline) and metanephrine concentrations, lipid oxidation rate, and cardiorespiratory variables during graded cycle exercise

STUDY TYPE

RCT

SPECIALTY

nutrition

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10030435

The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study

European Journal of Nutrition

READ THE FULL PAPER

ABSTRACT

Purpose Physical exercise is shown to mitigate catecholamine metabolites; however, it is unknown if exercise-induced increases in sympatho-adrenal activity or catecholamine metabolites are influenced by ingestion of specific catechins found within green tea. This study explored the impact of epigallocatechin gallate (EGCG) ingestion on catecholamine metabolism during graded cycle exercise in humans. Methods Eight males (22.4 ± 3.3 years, BMI:25.7 ± 2.4 kg.m 2 ) performed a randomised, placebo-controlled, single-blind, cross-over trial after consumption (1450 mg) of either EGCG or placebo (PLAC) and performed graded cycling to volitional exhaustion. Venous bloods were taken at rest, 2 h post-ingestion and after every 3-min stage. Blood variables were analysed for catecholamines, catecholamine metanephrines and metabolic variables at rest, 2 h post-ingestion (POST-ING), peak rate of lipid oxidation (FATpeak), lactate threshold (LT) and peak rate of oxygen consumption ( V O 2 peak). Data were analysed using SPSS (Version 26). Results Resting catecholamine and metanephrines were similar between trials. Plasma adrenaline (AD) was lower in ECGC treatment group between trials at FATpeak ( P < 0.05), LT ( P < 0.001) and V O 2 peak ( P < 0.01). Noradrenaline (NA) was lower under EGCG at POST ( P < 0.05), FATpeak ( P < 0.05), LT ( P < 0.01) and V O 2 peak ( P < 0.05) compared to PLAC. Metanephrines, glucose and lactate increased similarly with exercise intensity in both trials. Lipid oxidation rate was 32% lower in EGCG at FATpeak (EGCG 0.33 ± 0.14 vs. PLAC 0.49 ± 0.11 g.min −1 , P < 0.05). Cycle time to exhaustion was similar (NS). Conclusion Acute EGCG supplementation reduced circulating catecholamines but not; metanephrine, glucose or lactates, response to graded exercise. Lower circulating catecholamines may explain a lower lipid oxidation rate.

CITATION EXPORT

Rachel Churm, Liam M. Williams, Gareth Dunseath et al.. The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study. European Journal of Nutrition. (2023). https://doi.org/10.1007/s00394-023-03092-1

AUTHORS

5 · 3 CENTRES

Rachel Churm, Liam M. Williams, Gareth Dunseath, Sarah L. Prior, Richard M. Bracken

1grid.4827.90000 0001 0658 8800Applied Sports Technology Exercise and Medicine Research Centre (A-STEM), College of Engineering, Faculty of Science and Engineering, Swansea University, Engineering East, Bay Campus, Swansea, SA1 8EN UK
2grid.4827.90000 0001 0658 8800Diabetes Research Group, Swansea University, Singleton Park, Swansea, UK
3grid.4827.90000 0001 0658 8800Medical School, Swansea University, Grove Building, Swansea, UK