The potential immuno-stimulating effect of curcumin, piperine, and taurine combination in hepatocellular carcinoma; a pilot study

Discover. Oncology · 7 authors, 6 centres

AI SUMMARY

FIDELITY 100%

POPULATIONTwenty-six hepatocellular carcinoma patients aged 50–80 years, all positive for HCV, who failed other lines of treatment.

INTERVENTIONDaily administration of a combination capsule containing 5 g curcumin, 50 mg piperine, and 500 mg taurine, divided into three doses, for 3 months.

COMPARISONBaseline levels measured before administration.

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

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TL;DR

This phase II clinical trial administered a combination of curcumin, piperine, and taurine to 26 hepatocellular carcinoma patients for 3 months. The study found significant increases in immune-stimulating markers like CD4, CD8, and certain cytokines, along with decreases in markers associated with immune suppression and tumor progression.

Full summary

597 CHARS

Patients received a daily combination of curcumin (5 g), piperine (50 mg), and taurine (500 mg) for three months. The study measured changes in plasma levels of immune and tumor biomarkers at monthly intervals. Central results showed significant increases in CD4, CD8, IL-2, IL-12, and IFN-γ levels, and significant decreases in CD25, IL-6, VEGF-α, LDH, AFP, and miRNA-21 expression compared to baseline. No significant change was observed in FOXP3 expression. The findings suggest a potential immune-stimulating effect of the combination, warranting further research in larger, controlled trials.

PICO

PPOPULATION

Twenty-six hepatocellular carcinoma patients aged 50–80 years, all positive for HCV, who failed other lines of treatment.

IINTERVENTION

Daily administration of a combination capsule containing 5 g curcumin, 50 mg piperine, and 500 mg taurine, divided into three doses, for 3 months.

OOUTCOME

Plasma levels of immune markers (CD4, CD8, CD25, IL-2, IL-6, IL-12, IFN-γ), tumor markers (VEGF-α, LDH, AFP), and gene expression (FOXP3 mRNA, miRNA-21).

STUDY TYPE

RCT

SPECIALTY

oncology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10499730

The potential immuno-stimulating effect of curcumin, piperine, and taurine combination in hepatocellular carcinoma; a pilot study

Discover. Oncology

READ THE FULL PAPER

ABSTRACT

Abstract Background This is a phase II clinical trial to investigate the immunotherapeutic effect of Curcumin, Piperine, and Taurine (CPT) combination in hepatocellular carcinoma (HCC). Methods Twenty-six HCC patients aged (50–80 years) were recruited for administration of a daily dose of 5 g of curcumin, 50 mg of piperine, and 500 mg of taurine divided into three doses for successive 3 months. The three components (CPT) were prepared in one capsule. Patients were assessed after each month (cycle) for the plasma levels of CD4, CD8, CD25, Interleukins-2 (IL-2), IL-6, IL-12, Interferon-gamma (IFN- γ), Lactate dehydrogenase (LDH), and Vascular endothelial growth factor (VEGF), FOXP3 mRNA, and miRNA 21 . Results There was a significant increase in the plasma levels of CD4 and CD8, while a significant decrease in the CD25 level after the second and third cycles compared to the baseline level [P < 0.001 for both]. Also, there was a significant increase in the plasma levels of IL-2, IL-12, and IFN-γ [ P = 0.001, P = 0.006, and P = 0.029; respectively], while there was a significant decrease in IL-6, VEGF-α, LDH, and Alpha-fetoprotein (AFP) after CPT administration compared to the baseline levels [P < 0.001, P < 0.001, P = 0.020, and P = 0.004; respectively]. The expression level of miRNA-21 was significantly decreased after CPT administration compared to the baseline level [5.5±0.88, 4.1±0.78, 3±0.75, and 2.5±0.76; respectively, P<0.001]. Though there was a noticeable decrease in the FOXP3 expression after each cycle, however, it didn’t reach a significant level [5.3±0.8, 4.2±0.76, 3.2±0.67, and 2.5±0.79; respectively, P=0.184]. Conclusion CPT could exhibit a potential immune-stimulating effect in HCC patients. The current trial had been registered at the National Hepatology and Tropical Medicine Research Institute (NHTMRI), with a registration number of NHTMRI-IRB 2-21 on 5th January 2021. Supplementary Information The online version contains supplementary material available at 10.1007/s12672-023-00785-1. Keywords: Liver cancer, HCC, Curcumin, Immunomodulation, Piperine, Taurine

CITATION EXPORT

Raghda R kotb, Ahmed M Afifi, Motawa E EL-Houseini et al.. The potential immuno-stimulating effect of curcumin, piperine, and taurine combination in hepatocellular carcinoma; a pilot study. Discover. Oncology. (2023). https://doi.org/10.1007/s12672-023-00785-1

AUTHORS

7 · 6 CENTRES

Raghda R kotb, Ahmed M Afifi, Motawa E EL-Houseini, Mohamed Ezz-Elarab, Emad B Basalious, Mervat M Omran, Mona S Abdellateif

1Department of Zoology, Faculty of Science, Cairo University, Cairo, Egypt
2Medical Biochemistry and molecular biology, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
3National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt
4Pharmaceutics and Industrial Pharmacy department, Faculty of Pharmacy, Cairo University, Cairo, 11562 Egypt
5Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
6Biological science division, University of Chicago, Chicago, IL USA