Biology · 13 authors, 2 centres
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This narrative review summarizes preclinical and cellular research on the role of autophagy in female reproductive processes like decidualization and preeclampsia, highlighting that while accurate evaluation is possible in experimental models, it is difficult in human tissue samples.
This narrative review examines the role of autophagy in female reproduction, focusing on cellular and animal studies. It describes autophagy as a fundamental process for maintaining cellular homeostasis, involved in energy production and the degradation of cellular components. The review discusses evidence linking dysregulated autophagy to conditions like preeclampsia, citing preclinical findings that both inhibition and activation of autophagy may be involved. It emphasizes that evaluating autophagy is challenging in fixed human tissues. A key conclusion is that while the maintenance of normal autophagy is believed necessary for reproductive health, the exact contribution to conditions like preeclampsia remains controversial and requires further study.
