SEARCHNARRATIVE_REVIEWgastroenterology, oncology

narrative_review·gastroenterology, oncology, immunology, systematic review, biomedical research·PMC10046238

The Role of Genetic, Metabolic, Inflammatory, and Immunologic Mediators in the Progression of Intraductal Papillary Mucinous Neoplasms to Pancreatic Adenocarcinoma

Cancers · 6 authors, 3 centres

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This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

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TL;DR

This narrative review summarizes the biological pathways, including genetic, metabolic, inflammatory, and immunologic changes, that are involved in the progression of intraductal papillary mucinous neoplasms (IPMN) to pancreatic ductal adenocarcinoma (PDAC). It highlights that these pathways represent potential biomarkers to help stratify the risk of progression and guide management to avoid unnecessary surgery.

Full summary

725 CHARS

This narrative review synthesizes existing literature on the mechanisms driving the progression of intraductal papillary mucinous neoplasms (IPMN) to pancreatic ductal adenocarcinoma (PDAC). It describes genetic alterations, particularly in KRAS and GNAS, and their downstream effects on metabolic pathways such as lipid and glucose metabolism. The review also details how these changes, along with inflammation and immune modulation within the pancreatic microenvironment, contribute to tumorigenesis. A central implication is that understanding these molecular and metabolic profiles may lead to novel biomarkers for more accurate risk stratification of IPMNs, potentially reducing the rate of surgery for low-risk lesions.

STUDY TYPE

narrative_review

SPECIALTY

gastroenterology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10046238

The Role of Genetic, Metabolic, Inflammatory, and Immunologic Mediators in the Progression of Intraductal Papillary Mucinous Neoplasms to Pancreatic Adenocarcinoma

Cancers

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ABSTRACT

Simple Summary Intraductal papillary mucinous neoplasms (IPMN) are benign pancreatic cysts found in the ducts of the pancreas that have the potential to become malignant. Identifying IPMNs that have high potential to become pancreatic cancer may help prevent unnecessary surgery which is the definitive treatment of IPMNs. Currently, the management of IPMNs are dependent on variable factors including characteristics of the cyst, size of the pancreatic duct, and the presence or absence of obstructive jaundice. Identifying potential biomarkers may help more accurately distinguish high risk IPMNs from low risk IPMNs that do not need surgical intervention. This review summarized the various changes within IPMNs that promotes their progression to pancreatic adenocarcinoma. In addition, this review highlighted potential biomarkers that can distinguish IPMNs that have a high risk of becoming cancerous. Abstract Intraductal papillary mucinous neoplasms (IPMN) have the potential to progress to pancreatic ductal adenocarcinoma (PDAC). As with any progression to malignancy, there are a variety of genetic and metabolic changes, as well as other disruptions to the cellular microenvironment including immune alterations and inflammation, that can contribute to tumorigenesis. Previous studies further characterized these alterations, revealing changes in lipid and glucose metabolism, and signaling pathways that mediate the progression of IPMN to PDAC. With the increased diagnosis of IPMNs and pancreatic cysts on imaging, the opportunity to attenuate risk with the removal of high-risk lesions is possible with the understanding of what factors accelerate malignant progression and how they can be clinically utilized to determine the level of dysplasia and stratify the risk of progression. Here, we reviewed the genetic, metabolic, inflammatory, and immunologic pathways regulating the progression of IPMN to PDAC.

CITATION EXPORT

Kylie E. Shockley, Briana To, Wei Chen et al.. The Role of Genetic, Metabolic, Inflammatory, and Immunologic Mediators in the Progression of Intraductal Papillary Mucinous Neoplasms to Pancreatic Adenocarcinoma. Cancers. (2023). https://doi.org/10.3390/cancers15061722

AUTHORS

6 · 3 CENTRES

Kylie E. Shockley, Briana To, Wei Chen, Gerard Lozanski, Zobeida Cruz-Monserrate, Somashekar G. Krishna

1Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
2Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
3Division of Gastroenterology, Hepatology, and Nutrition, and The James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA

EDITOR / REVIEWER

Elisa Dalla Pozza, Ilaria Dando