SEARCHNARRATIVE_REVIEWoncology, endocrinology

narrative_review·oncology, endocrinology, biomedical research, preclinical research·PMC10180081

The Role of MMP-9 and MMP-9 Inhibition in Different Types of Thyroid Carcinoma

Molecules · 7 authors, 1 centre

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TL;DR

It also reviews the therapeutic potential of various MMP-9 inhibitors in preclinical models of thyroid cancer.

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The review also summarizes various natural and non-natural MMP-9 inhibitors, highlighting their potential to inhibit thyroid cancer cell viability, adhesion, migration, invasion, and angiogenesis, while promoting apoptosis. The review suggests that MMP-9 inhibitors represent a promising therapeutic avenue pending further clinical development.

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narrative_review

SPECIALTY

oncology

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AI pipeline

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100% · A

ORIGINAL PAPER

PMC10180081

The Role of MMP-9 and MMP-9 Inhibition in Different Types of Thyroid Carcinoma

Molecules

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ABSTRACT

Abstract Matrix metalloproteinase-9 (MMP-9), one of the most investigated and studied biomarkers of the MMPs family, is a zinc-dependent proteolytic metalloenzyme whose primary function is degrading the extracellular matrix (ECM). It has been proved that MMP-9 expression elevates in multiple pathological conditions, including thyroid carcinoma. MMP-9 has a detectable higher level in malignant or metastatic thyroid tumor tissues than in normal or benign tissues and acts as an additional marker to distinguish different tumor stages because of its close correlations with clinical features, such as lymph node metastasis, TNM stage, tumor size and so on. Natural and non-natural MMP-9 inhibitors suppress its expression, block the progression of diseases, and play a role in therapy consequently. MMP-9 inhibitory molecules also assist in treating thyroid tumors by suppressing the proliferation, invasion, migration, metastasis, viability, adhesion, motility, epithelial-mesenchymal transition (EMT), and other risk factors of different thyroid cancer cells. In a word, discovering and designing MMP-9 inhibitors provide great therapeutic effects and promising clinical values in various types of thyroid carcinoma. Keywords: matrix metalloproteinase-9, MMP-9 inhibitor, thyroid carcinoma

CITATION EXPORT

Zhenshengnan Li, Jia Wei, Bowen Chen et al.. The Role of MMP-9 and MMP-9 Inhibition in Different Types of Thyroid Carcinoma. Molecules. (2023). https://doi.org/10.3390/molecules28093705

AUTHORS

7 · 1 CENTRES

Zhenshengnan Li, Jia Wei, Bowen Chen, Yaoqi Wang, Shuai Yang, Kehui Wu, Xianying Meng

1Department of Thyroid Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, China; [email protected] (Z.L.);