Life · 2 authors, 2 centres
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This narrative review describes how oxidative stress drives normal age-related anatomical changes and pathologies in the anterior and posterior segments of the human eye. It concludes that therapies targeting oxidative stress could slow the progression of age-related ocular diseases like cataracts, glaucoma, and macular degeneration.
This narrative review synthesizes literature on age-related changes in the human eye, focusing on the anterior and posterior segments. The authors describe anatomical and functional changes, such as lens stiffening, vitreous liquefaction, and retinal cell loss, driven by reactive oxygen species. It highlights that age-related ocular pathologies, including cataracts, glaucoma, and age-related macular degeneration, are largely mediated by oxidative stress. The review notes that the prevalence of these diseases is expected to increase with the aging population. The implication is that developing therapies addressing oxidative stress is a key target for preventing or slowing these age-related pathologies.
