SEARCHNARRATIVE_REVIEWnutrition, antioxidants

narrative_review·nutrition, antioxidants, vitamins, preclinical research, public health·PMC10464721

THE ROLE OF WELL-KNOWN ANTIOXIDANT VITAMINS IN THE PREVENTION OF CADMIUM-INDUCED TOXICITY

International Journal of Occupational Medicine and Environmental Health · 2 authors, 1 centre

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TL;DR

This narrative review synthesizes evidence from 50 animal studies and 7 human studies on whether antioxidant vitamins (A, C, E, β-carotene) can reduce toxicity caused by cadmium.

Full summary

199 CHARS

The synthesis indicates that most animal studies demonstrate beneficial effects, with vitamins reducing adverse changes in multiple organ systems and improving hematological and metabolic parameters.

STUDY TYPE

narrative_review

SPECIALTY

nutrition

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AI pipeline

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ORIGINAL PAPER

PMC10464721

THE ROLE OF WELL-KNOWN ANTIOXIDANT VITAMINS IN THE PREVENTION OF CADMIUM-INDUCED TOXICITY

International Journal of Occupational Medicine and Environmental Health

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ABSTRACT

Abstract Long-term exposure to cadmium (Cd) leads to the development of a number of conditions associated with liver and kidney damage, reproductive and cardiovascular disorders, in addition to visual impairment, blindness and hearing loss, among others. Cadmium has been classified as a human carcinogen by the International Agency for Research on Cancer. The toxicity of Cd is related to its pro-oxidant properties and the associated increase in oxidative stress. Antioxidant ingredients may be helpful in preventing the adverse effects of Cd. The effect of well-known antioxidant vitamins (E, C, A and β-carotene) in the prevention of Cd-induced toxicity is presented in this study. Numerous studies in animal models have shown that the effects of vitamins: E, C, A, and β-carotene were effective in reducing Cd concentrations in organs and tissues and reduced Cd-induced changes in liver, kidney, and reproductive, circulatory, nervous, immune, and respiratory systems. In contrast, the limited number of human studies does not allow to accurately determine the role of these nutrients in reducing Cd-induced toxicity, indicating the need for further studies clarifying the role of antioxidant vitamins in reducing Cd-induced toxicity. However, it seems reasonable to promote the consumption of natural food products that are sources of antioxidant vitamins in groups of people with occupational and environmental exposure to Cd. Keywords: vitamin A, β-carotene, vitamin E, vitamin C, oxidative stress, cadmium exposure

CITATION EXPORT

Agnieszka Sitek, Lucyna Kozłowska. THE ROLE OF WELL-KNOWN ANTIOXIDANT VITAMINS IN THE PREVENTION OF CADMIUM-INDUCED TOXICITY. International Journal of Occupational Medicine and Environmental Health. (2022). https://doi.org/10.13075/ijomeh.1896.01912

AUTHORS

2 · 1 CENTRES

Agnieszka Sitek, Lucyna Kozłowska

1Warsaw University of Life Sciences (WULS – SGGW), Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw, Poland