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TL;DR
The central conclusion is that lactate acts as an active oncometabolite promoting tumorigenesis and that preliminary evidence links elevated circulating lactate to worse prognosis in breast cancer patients.
International Journal of Molecular Sciences · 4 authors, 4 centres
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The central conclusion is that lactate acts as an active oncometabolite promoting tumorigenesis and that preliminary evidence links elevated circulating lactate to worse prognosis in breast cancer patients.
The authors describe how cancer cells shift toward glycolytic metabolism, producing lactate that acidifies the extracellular matrix, with extracellular tumor concentrations reaching up to 40 mM compared to 1.5–3 mM in non-malignant tissues. The authors identify a positive correlation between hyperlactacidemia and poor prognosis in breast cancer patients, though they note no clear causal linkage has been established.