Food Science & Nutrition · 9 authors, 4 centres
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This preclinical study investigated the antiobesity effects of Mallotus furetianus extract (MFE) in obesity model mice and 3T3-L1 preadipocytes. The central finding is that MFE suppresses adipocyte differentiation by reducing the protein levels of the transcription factor C/EBPβ through posttranslational modifications, thereby inhibiting the downstream expression of PPARγ and C/EBPα and reducing triglyceride synthesis.
This study investigated the antiobesity effects of Mallotus furetianus extract (MFE) using an in vivo obesity model with high-fat diet-fed mice and an in vitro model with 3T3-L1 preadipocytes. In vivo, MFE treatment significantly suppressed the increase in body weight and adipose tissue weight and inhibited fatty liver development. In vitro, MFE suppressed the differentiation of preadipocytes and the synthesis of triglycerides. The central mechanistic finding was that MFE decreases the protein level of the transcription factor C/EBPβ via posttranslational modifications (PTMs), specifically by reducing phosphorylation of ERK and suppressing the expression of the deSUMOylase SENP2. This reduction in functional C/EBPβ subsequently led to suppressed transcriptional expression of the master adipogenic regulators PPARγ and C/EBPα. The authors concluded that MFE exerts an antiobesity effect by controlling C/EBPβ PTMs in the early stage of adipocyte differentiation. Limitations include the use of a preclinical model and the observation of an unexpected increase in feed efficiency and adipocyte size with MFE in the control-diet group, which was not fully explained.
