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TL;DR
The central finding is that Para localizes to both an axonal initial segment-like region and a novel dendritic spike initiation zone in chordotonal neuron dendrites, overlapping with mechanosensitive TRP channels.
eNeuro · 5 authors, 4 centres
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The central finding is that Para localizes to both an axonal initial segment-like region and a novel dendritic spike initiation zone in chordotonal neuron dendrites, overlapping with mechanosensitive TRP channels.
In multipolar and bipolar peripheral neurons, Para localized to an axonal initial segment-like region proximal to the soma, serving as the likely spike initiation zone. A key novel finding was the presence of Para in the dendrites of bipolar chordotonal neurons, specifically at the distal tip, forming a dendritic spike initiation zone that overlaps with mechanosensitive TRP channels NompC and Iav. This dendritic localization is unique to chordotonal neurons. Limitations include the inability to functionally separate Para's roles in the axon versus dendrite with current tools, and the fact that mechanistic interplay with TRP channels remains to be established.