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TL;DR
This narrative review summarizes recent preclinical studies showing that plant extracts and natural substances promote wound healing in animal models (mice, rats, rabbits) through anti-inflammatory, antimicrobial, and antioxidant mechanisms.
Inflammopharmacology · 2 authors, 1 centre
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This narrative review summarizes recent preclinical studies showing that plant extracts and natural substances promote wound healing in animal models (mice, rats, rabbits) through anti-inflammatory, antimicrobial, and antioxidant mechanisms.
This is a narrative review of 190 in vivo studies from the last 5 years examining the wound-healing effects of botanical extracts and natural substances in animal models. The review highlights that these natural products, through activities like scavenging reactive oxygen species and reducing inflammation, can improve wound contraction, epithelial proliferation, and collagen formation. It also notes that incorporating these agents into advanced wound dressings (e.g., nanofibers, hydrogels) shows promise in various healing phases. The evidence is derived entirely from preclinical animal models, including diabetic and non-diabetic rats, mice, and rabbits, with or without infection. The authors conclude that these natural agents are potent wound-healing candidates and call for future research to confirm safety and efficacy through rigorous clinical trials, moving from preclinical findings to potential human applications.