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TL;DR
In a rat model of indomethacin-induced intestinal inflammation, oral administration of bromelain or papain reduced oxidative stress and inflammatory biomarkers, with bromelain demonstrating the most potent protective effect.
International Journal of Health Sciences · 3 authors, 3 centres
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In a rat model of indomethacin-induced intestinal inflammation, oral administration of bromelain or papain reduced oxidative stress and inflammatory biomarkers, with bromelain demonstrating the most potent protective effect.
Forty male rats were divided into five groups of eight: healthy control, indomethacin-induced intestinal inflammation, indomethacin plus bromelain (1000 mg/kg/day), indomethacin plus papain (800 mg/kg/day), and indomethacin plus sulfasalazine (500 mg/kg/day). Indomethacin significantly elevated oxidative stress biomarkers (XO, CAT, RG, PC) and inflammatory biomarkers (IL-10, TNF-α, MCP-1, NF-kβ, CRP, PGE2, MPO). Treatment with either bromelain or papain reduced all measured oxidative stress and inflammatory biomarkers compared to the indomethacin-only group. Between the two enzyme treatments, bromelain showed significantly greater reductions in XO, CAT, PC, IL-10, TNF-α, PG, NF-kβ, CRP, and MPO. Sulfasalazine served as a positive control with partial normalization.