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TL;DR
The central conclusion is that diet-based microbiota interventions represent a promising and potentially safer alternative to drug-based therapies for Alzheimer's disease.
Life · 2 authors, 2 centres
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The central conclusion is that diet-based microbiota interventions represent a promising and potentially safer alternative to drug-based therapies for Alzheimer's disease.
This narrative review examines evidence from experimental Alzheimer's disease (AD) models on the role of gut microbiota in neuroinflammation and neurodegeneration. These diet-based interventions are characterized as generally safe and potentially more advantageous than drug-based therapies. The discussion of circadian control of oxidative or proteotoxic stress suggests additional avenues for novel time-based therapeutic interventions.