SEARCHCROSS-SECTIONALophthalmology, cornea

cross-sectional·ophthalmology, cornea, endocrinology, vitamins, clinical trial·PMC10220045

Thyroid gland dysfunction and vitamin D receptor gene polymorphism in keratoconus

Eye · 6 authors, 2 centres

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TL;DR

This cross-sectional study investigated associations between thyroid function, serum vitamin D levels, vitamin D receptor (VDR) polymorphisms, and keratoconus (KC).

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This cross-sectional study investigated associations between thyroid function, serum vitamin D levels, vitamin D receptor (VDR) polymorphisms, and keratoconus (KC). Serum TSH, FT3, FT4, and 25(OH) vitamin D were measured, and VDR polymorphisms (Taq I, Apa I, Bsm I) were genotyped. Results showed significantly higher frequency of thyroid disorders, lower serum 25(OH) vitamin D levels, and a higher prevalence of the VDR Taq1 tt genotype in KC patients versus controls. Logistic regression analysis identified TSH, FT4, hypothyroidism, vitamin D insufficiency, and deficiency as significant risk factors for KC. The findings suggest thyroid dysfunction and low vitamin D are associated with KC, and VDR polymorphisms may be a genetic factor, warranting further research.

STUDY TYPE

cross-sectional

SPECIALTY

ophthalmology

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100% · A

ORIGINAL PAPER

PMC10220045

Thyroid gland dysfunction and vitamin D receptor gene polymorphism in keratoconus

Eye

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ABSTRACT

Abstract Objectives To detect the serum level of thyroid hormones, vitamin D and vitamin D receptors (VDR) polymorphism in keratoconus (KC) patients and to identify the association between vitamin D deficiency and thyroid dysfunction in KC. Methods This cross sectional study included 177 KC patients with no thyroid disorders compared to 85 healthy controls with normal corneal tomography. Measurements of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free tetraiodothyronine (FT4) and serum 25-OH vitamin D were done using Enzyme linked immusoassay (ELISA test). VDR polymorphisms were tested including [Taq I (rs731236), Apa I (rs7975232) and Bsm I (rs1544410)] using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results An increase in frequency of thyroid disorders ( P = 0.04), decrease in serum 25(OH) vitamin D level ( P < 0.001), Taq 1 and tt genotype ( P < 0.001) were significantly distributed in KC patients. A significantly higher serum 25(OH) vitamin D level was reported in TT genotype, while insufficient level was more common in Tt genotype ( P < 0.001). A deficient serum 25(OH) vitamin D level was predominant in tt genotype ( P < 0.001). A 95% confidence interval was in TSH (1.603, 2.946), FT4 (24.145, 77.06), hypothyroidism (1.062, 67.63), insufficient (2.936, 11.643) and deficient vitamin D (5.283, 28.704) and all were significant risk factors for KC with ( P < 0.05). Conclusions Both thyroid disorders and low vitamin D are potential factors for KC development. Studying VDR at the molecular level provides interesting avenues for future research toward the identification of new KC cases. Subject terms: Gene expression, Corneal diseases

CITATION EXPORT

Eman A Awad, Magda A Torky, Rania M Bassiouny et al.. Thyroid gland dysfunction and vitamin D receptor gene polymorphism in keratoconus. Eye. (2022). https://doi.org/10.1038/s41433-022-02172-6

AUTHORS

6 · 2 CENTRES

Eman A Awad, Magda A Torky, Rania M Bassiouny, Abeer M Khattab, Rasha R Elzehery, Rania M Elhelaly

1Department of Ophthalmology, Mansoura Ophthalmic Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt
2Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt