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narrative_review·neurology, preclinical research, biomedical research·PMC10611582

Timing to be precise? An overview of spike timing-dependent plasticity, brain rhythmicity, and glial cells interplay within neuronal circuits

Molecular Psychiatry · 3 authors, 2 centres

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Central results indicate that astrocytes provide key molecules (e.g., D-serine, adenosine) that mediate developmental switches in STDP polarity and that microglia-derived ATP influences synaptic plasticity. The review also discusses how brain rhythms create a temporal structure for neuronal firing.

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narrative_review

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neurology

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ORIGINAL PAPER

PMC10611582

Timing to be precise? An overview of spike timing-dependent plasticity, brain rhythmicity, and glial cells interplay within neuronal circuits

Molecular Psychiatry

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ABSTRACT

Abstract In the mammalian brain information processing and storage rely on the complex coding and decoding events performed by neuronal networks. These actions are based on the computational ability of neurons and their functional engagement in neuronal assemblies where precise timing of action potential firing is crucial. Neuronal circuits manage a myriad of spatially and temporally overlapping inputs to compute specific outputs that are proposed to underly memory traces formation, sensory perception, and cognitive behaviors. Spike-timing-dependent plasticity (STDP) and electrical brain rhythms are suggested to underlie such functions while the physiological evidence of assembly structures and mechanisms driving both processes continues to be scarce. Here, we review foundational and current evidence on timing precision and cooperative neuronal electrical activity driving STDP and brain rhythms, their interactions, and the emerging role of glial cells in such processes. We also provide an overview of their cognitive correlates and discuss current limitations and controversies, future perspectives on experimental approaches, and their application in humans. Subject terms: Physiology, Neuroscience, Cell biology

CITATION EXPORT

Yuniesky Andrade-Talavera, André Fisahn, Antonio Rodríguez-Moreno. Timing to be precise? An overview of spike timing-dependent plasticity, brain rhythmicity, and glial cells interplay within neuronal circuits. Molecular Psychiatry. (2023). https://doi.org/10.1038/s41380-023-02027-w

AUTHORS

3 · 2 CENTRES

Yuniesky Andrade-Talavera, André Fisahn, Antonio Rodríguez-Moreno

1Laboratory of Cellular Neuroscience and Plasticity, Department of Physiology, Anatomy and Cell Biology, Universidad Pablo de Olavide, ES-41013 Seville, Spain
2Department of Biosciences and Nutrition and Department of Women’s and Children’s Health, Karolinska Institutet, 171 77 Stockholm, Sweden

Yuniesky Andrade-Talavera, André Fisahn, Antonio Rodríguez-Moreno. Timing to be precise? An overview of spike timing-dependent plasticity, brain rhythmicity, and glial cells interplay within neuronal circuits. Molecular Psychiatry. (2023). https://doi.org/10.1038/s41380-023-02027-w