Investigative Ophthalmology & Visual Science · 7 authors, 2 centres
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This preclinical study used targeted metabolomics to quantify 133 metabolites in mouse eye and brain tissues from males and females under fed and fasted conditions. It found numerous sex-specific metabolic differences, with some being tissue-specific and others common across tissues, suggesting a strong influence of sex on ocular and brain metabolism.
This targeted metabolomics study analyzed 133 metabolites in mouse eye tissues (retina, RPE/choroid, lens), brain, and plasma under fed and fasted conditions to identify sex-specific and tissue-specific metabolic differences. Thirty-three metabolites were altered in two or more tissues, while 64 were tissue-specific. Pantothenic acid, hypotaurine, and 4-hydroxyproline were the most commonly changed metabolites. The lens and retina had the most tissue-specific sex-different metabolites, enriched in amino acid, nucleotide, lipid, and TCA cycle metabolism. The female RPE and female brain showed greater sensitivity to fasting, with more decreased metabolites in amino acid metabolism, TCA cycles, and glycolysis. Plasma showed the fewest sex-different metabolites. The study concludes that sex strongly influences eye and brain metabolism in tissue-specific and state-specific ways, which may have implications for understanding sexual dimorphisms in ocular physiology and disease susceptibility.
