Journal of Lipid Research · 17 authors, 3 centres
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This preclinical study used a virus strategy to delete TLR4 in POMC neurons of mice and found sex-dependent effects on thermogenesis and lipid homeostasis. In male mice, deletion increased energy expenditure and activated brown adipose tissue thermogenesis, while in female mice, it decreased energy expenditure and increased body weight.
This preclinical study investigated the specific role of TLR4 in hypothalamic POMC neurons using a virus-mediated deletion strategy in mice. In male mice, deletion of TLR4 activated the sympathetic nervous system, increased expression of thermogenic markers like UCP1, and led to higher energy expenditure and lower body weight. Conversely, in female mice, the same deletion altered lipid homeostasis in inguinal white adipose tissue, resulting in decreased energy expenditure and increased body weight.
