Frontiers in Neurology · 13 authors, 6 centres
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This paper describes two clinical studies evaluating a wearable device (PDMonitor) for monitoring motor symptoms in Parkinson's disease. The device demonstrated high accuracy and correlation with clinical assessments for detecting symptoms like bradykinesia, gait impairment, and dyskinesia, and was found to be easy for patients to use.
The study validated the PDMonitor wearable system across two multi-site clinical studies involving 65 Parkinson's disease (PD) patients and 28 healthy controls. In a supervised clinic phase, device estimations of symptom severity were compared to clinical ratings (UPDRS Part III, AIMS). In unsupervised home phases, day-to-day variability was assessed. For example, accuracy for OFF and dyskinesia time estimation was high (r² = 0.75 and r² = 0.63, respectively). The device was also confirmed to be wearable and easy to use, with automatic sensor placement identification. Limitations include the need for further real-world evaluation of usability factors like stigma and the fact that the device does not replace clinical examination. The findings support the system's potential as a telemonitoring tool to facilitate clinical decision-making.
