SEARCHOTHERgastroenterology, epidemiology

other·gastroenterology, epidemiology, immunology, biomedical research, observational study·PMC10470767

Trimethylamine N-oxide and risk of inflammatory bowel disease: A Mendelian randomization study

Medicine · 7 authors, 1 centre

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

The main analysis found no significant association, but a sensitivity analysis suggested a potential inverse association.

Full summary

110 CHARS

The discussion considers potential biological pathways, including gut microbiome metabolism and FXR signaling.

STUDY TYPE

other

SPECIALTY

gastroenterology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10470767

Trimethylamine N-oxide and risk of inflammatory bowel disease: A Mendelian randomization study

Medicine

READ THE FULL PAPER

ABSTRACT

Abstract A previous study suggested that inflammatory bowel disease (IBD) patients have low plasma levels of trimethylamine N-oxide (TMAO). In the present study, we examined this hypothesis using Mendelian randomization analysis. We used summary statistics data for single-nucleotide polymorphisms associated with plasma levels of TMAO, and the corresponding data for IBD from a genome-wide association meta-analysis of 59,957 individuals (25,042 diagnosed IBD cases, 34,915 controls). The association between genetically predicted plasma TMAO levels and IBD showed odds ratios (95% confidence interval [CI]) per 1 interquartile range increment (per 2.4 μmol/L) in TMAO levels were 0.91 (0.81–1.01, P = .084) for IBD, 0.88 (0.76–1.02, P = .089) for ulcerative colitis, 0.91 (0.79–1.05, P = .210) for Crohn disease. There was no evidence for pleiotropy based on the Mendelian randomization-Egger regression analyses (P-intercept = 0.669 for IBD). Further investigations would be needed to understand the causal relationship between TMAO and IBD. Keywords: Crohn disease, genome-wide association studies, inflammatory bowel disease, Mendelian randomization, trimethylamine N-oxide, ulcerative colitis

CITATION EXPORT

Yukika Banno, Miho Nomura, Risako Hara et al.. Trimethylamine N-oxide and risk of inflammatory bowel disease: A Mendelian randomization study. Medicine. (2023). https://doi.org/10.1097/MD.0000000000034758

AUTHORS

7 · 1 CENTRES

Yukika Banno, Miho Nomura, Risako Hara, Momoko Asami, Kotone Tanaka, Yuuka Mukai, Yasutake Tomata

a School of Nutrition and Dietetics, Faculty of Health and Social Services, Kanagawa University of Human Services, Yokosuka, Kanagawa, Japan.