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TL;DR
This narrative review synthesizes literature on how cell cycle regulators (notably Cdk1) and metabolic pathways are bidirectionally coupled in Saccharomyces cerevisiae.
Frontiers in Microbiology · 3 authors, 3 centres
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This narrative review synthesizes literature on how cell cycle regulators (notably Cdk1) and metabolic pathways are bidirectionally coupled in Saccharomyces cerevisiae.
Cdk1 phosphorylates and activates Tgl4 at bud onset to mobilize fatty acids from triacylglycerol, and phosphorylates and inactivates Pah1 in G2 phase to promote phospholipid synthesis. Cys4 controls G1 phase length through cysteine/glutathione synthesis and SAM homeostasis. The authors note that these links are likely conditionally active depending on cell cycle phase and metabolic state, and suggest that conserved mechanisms may inform understanding of mammalian cell cycle–metabolism coordination.