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TL;DR
K48-linked polyubiquitination typically signals for proteasomal degradation of ATG proteins, while K63-linked polyubiquitination is associated with ATG protein activation and autophagy initiation.
Acta Biochimica et Biophysica Sinica · 3 authors, 2 centres
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K48-linked polyubiquitination typically signals for proteasomal degradation of ATG proteins, while K63-linked polyubiquitination is associated with ATG protein activation and autophagy initiation.
K48-linked polyubiquitination typically signals for proteasomal degradation of ATG proteins, while K63-linked polyubiquitination is associated with ATG protein activation and autophagy initiation. The review explains how these modifications create a regulatory loop between the ubiquitin-proteasome system (UPS) and autophagy, where inhibition of autophagy can lead to the accumulation of ubiquitinated proteins like p62, impairing proteasomal function.