Umbilical venous catheter- and peripherally inserted central catheter-associated complications in preterm infants with birth weight < 1250 g

Wiener Medizinische Wochenschrift (1946) · 22 authors, 18 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

PICC-associated bacterial infection rates were substantially higher than UVC rates, while UVC thrombosis rates were higher than PICC rates.

Full summary

713 CHARS

This was an electronic survey of senior neonatologists at 20 NeoVitaA trial centers (12 responded; 60% response rate) in Austria and Germany, assessing UVC- and PICC-associated complication rates in preterm infants with birth weight < 1250 g. Complication rates were higher than those previously reported in published literature. Limitations include the retrospective, expert-estimated nature of reported data, a limited number of reporting centers, and potential selection bias as participating sites were all NeoVitaA centers and do not represent the full spectrum of more than 150 tertiary NICUs in Austria and Germany. These findings serve as a basis for sample size calculation for a planned multicenter RCT.

STUDY TYPE

other

SPECIALTY

pediatrics

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10147741

Umbilical venous catheter- and peripherally inserted central catheter-associated complications in preterm infants with birth weight < 1250 g

Wiener Medizinische Wochenschrift (1946)

READ THE FULL PAPER

ABSTRACT

Abstract Background and objective Umbilical venous catheters (UVC) and peripherally inserted central catheters (PICC) are commonly used in preterm infants but have been associated with a number of serious complications. We performed a survey in Austria and Germany to assess the use of UVCs and PICCs in preterm infants with a birth weight < 1250 g and associated rates of catheter-related adverse events. Methods Electronic survey of participating centers of the NeoVitaA trial. Main outcome parameter was the reported rates of UVC- and PICC-associated complications (infection, thrombosis, emboli, organ injury, arrhythmia, dislocation, miscellaneous). Results In total, 20 neonatal intensive care units (NICU) providing maximal intensive care in Austria and Germany (level I) were contacted, with a senior neonatologist response rate of 12/20 (60%). The reported rates for UVC with a dwell time of 1–10 days were bacterial infection: 4.2 ± 3.4% (range 0–10%); thrombosis: 7.3 ± 7.1% (0–20%); emboli: 0.9 ± 2.0% (0–5%); organ injury: 1.1 ± 1.9% (0–5%); cardiac arrhythmia: 2.2 ± 2.5% (0–5%); and dislocation: 5.4 ± 8.7% (0–30%); and for PICCs with a dwell time of 1–14 days bacterial infection: 15.0 ± 3.4% (range 2.5–30%); thrombosis; 4.3 ± 3.5% (0–10%); emboli: 0.8 ± 1.6% (0–5%); organ injury: 1.5 ± 2.3% (0–5%); cardiac arrhythmia: 1.5 ± 2.3% (0–5%), and dislocation: 8.5 ± 4.6% (0–30%). Conclusion The catheter-related complication rates reported in this survey differed between UVCs and PICCs and were higher than those reported in the literature. To generate more reliable data on this clinically important issue, we plan to perform a large prospective multicenter randomized controlled trial investigating the non-inferiority of a prolonged UVC dwell time (up to 10 days) against the early change (up to 5 days) to a PICC. Supplementary Information The online version of this article (10.1007/s10354-022-00952-z) contains supplementary material, which is available to authorized users. Keywords: Survey, Very low birth weight infants, Umbilical venous catheter, Peripherally inserted central catheter, Infection, Thrombosis, Emboli, Organ injury

CITATION EXPORT

Steffi Hess, Martin Poryo, Ralf Böttger et al.. Umbilical venous catheter- and peripherally inserted central catheter-associated complications in preterm infants with birth weight < 1250 g. Wiener Medizinische Wochenschrift (1946). (2022). https://doi.org/10.1007/s10354-022-00952-z

AUTHORS

22 · 18 CENTRES

Steffi Hess, Martin Poryo, Ralf Böttger, Axel Franz, Daniel Klotz, Knud Linnemann, Torsten Ott, Johannes Pöschl, Michael Schroth, Anja Stein, Elisabeth Ralser, Heiko Reutter, Ulrich H Thome, Christian Wieg, Anne Ehrlich, Christian Ruckes, Stefan Wagenpfeil, Michael Zemlin, Cihan Papan, Arne Simon, Johannes Bay, Sascha Meyer

1Department of General Pediatrics and Neonatology, Saarland University Medical Center, Kirrberger Str., Building 9, 66421 Homburg, Germany
2Department of Pediatric Cardiology, Saarland University Medical Center, Homburg, Germany
3University Children’s Hospital, Otto von Guericke University Magdeburg, Magdeburg, Germany
4University Children’s Hospital, Eberhard Karls University Tübingen, Tübingen, Germany
5Department of Neonatology, Center for Pediatrics, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
6University Children’s Hospital, Greifswald University Hospital, Greifswald, Germany
7University Children’s Hospital, University Hospital Muenster, Münster, Germany
8University Children’s Hospital, Heidelberg University Hospital, Heidelberg, Germany
9Children’s Hospital Nürnberg, Nürnberg, Germany
10University Children’s Hospital, Essen University Hospital, Essen, Germany
11University Children’s Hospital, Medical University of Innsbruck, Innsbruck, Austria
12Division of Neonatology and Pediatric Intensive Care Medicine, Department of Pediatric and Adolescent Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
13University Children’s Hospital, University of Leipzig Medical Center, Leipzig, Germany
14Children’s Hospital Aschaffenburg, Aschaffenburg, Germany
15Interdisziplinäres Zentrum für Klinische Studien (IZKS), Johannes Gutenberg-Universität, Mainz, Germany
16Institute for Medical Biometry, Epidemiology and Medical Informatics, Saarland University Medical Center, Homburg/Saar, Germany
17Department of Medical Microbiology and Hospital Hygiene, Saarland University Medical Center, Homburg, Germany
18Department of Pediatric Hematology and Oncology, Infectious Diseases, Saarland University Medical Center, Homburg, Germany