SEARCHNARRATIVE_REVIEWpreclinical research, research methods

narrative_review·preclinical research, research methods, biomedical research, neurology, clinical trial·PMC10295129

Universal Recommendations on Planning and Performing the Auditory Brainstem Responses (ABR) with a Focus on Mice and Rats

Audiology Research · 2 authors, 2 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

Full summary

324 CHARS

It concludes that standardizing experimental design, conduct, and reporting according to guidelines like ARRIVE is essential for translating animal research into clinical applications and reducing animal usage. The review does not present new experimental data but synthesizes existing knowledge to establish best practices.

STUDY TYPE

narrative_review

SPECIALTY

preclinical research

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10295129

Universal Recommendations on Planning and Performing the Auditory Brainstem Responses (ABR) with a Focus on Mice and Rats

Audiology Research

READ THE FULL PAPER

ABSTRACT

Abstract Translational audiology research aims to transfer basic research findings into practical clinical applications. While animal studies provide essential knowledge for translational research, there is an urgent need to improve the reproducibility of data derived from these studies. Sources of variability in animal research can be grouped into three areas: animal, equipment, and experimental. To increase standardization in animal research, we developed universal recommendations for designing and conducting studies using a standard audiological method: auditory brainstem response (ABR). The recommendations are domain-specific and are intended to guide the reader through the issues that are important when applying for ABR approval, preparing for, and conducting ABR experiments. Better experimental standardization, which is the goal of these guidelines, is expected to improve the understanding and interpretation of results, reduce the number of animals used in preclinical studies, and improve the translation of knowledge to the clinic. Keywords: auditory brainstem responses, ABR, translational audiology, experimental audiology, rodents

CITATION EXPORT

Ewa Domarecka, Agnieszka J Szczepek. Universal Recommendations on Planning and Performing the Auditory Brainstem Responses (ABR) with a Focus on Mice and Rats. Audiology Research. (2023). https://doi.org/10.3390/audiolres13030039

AUTHORS

2 · 2 CENTRES

Ewa Domarecka, Agnieszka J Szczepek

1Department of Otorhinolaryngology, Head and Neck Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, 10117 Berlin, Germany
2Faculty of Medicine and Health Sciences, University of Zielona Gora, 65-046 Zielona Gora, Poland