SEARCHCROSS-SECTIONALepidemiology, cardiology

cross-sectional·epidemiology, cardiology, public health, internal medicine·PMC10030668

Unravelling the link between periodontitis and abdominal aortic calcification in the US adult population: a cross-sectional study based on the NHANES 2013–2014

BMJ Open · 6 authors, 1 centre

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TL;DR

Periodontitis was classified using CDC/AAP case definitions, and AAC was assessed on lateral spine DXA images using AAC-8 and AAC-24 scoring tools.

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Periodontitis was classified using CDC/AAP case definitions, and AAC was assessed on lateral spine DXA images using AAC-8 and AAC-24 scoring tools. In fully adjusted logistic regression models, severe periodontitis was associated with severe AAC (AAC-24 score >6: OR 3.60; AAC-8 score ≥3: OR 2.53), and mild–moderate periodontitis was associated with severe AAC on the AAC-24 score (OR 2.25). Linear regression showed a significant positive correlation between severe periodontitis and both AAC scores in the age-, sex-, and race-adjusted model, though this association attenuated in models with additional covariate adjustment. No multiplicative interactions were found in subgroup analyses. Limitations include the cross-sectional design precluding causal inference, potential selection bias, and the relatively small proportion of participants with both severe periodontitis and severe AAC.

STUDY TYPE

cross-sectional

SPECIALTY

epidemiology

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100% · A

ORIGINAL PAPER

PMC10030668

Unravelling the link between periodontitis and abdominal aortic calcification in the US adult population: a cross-sectional study based on the NHANES 2013–2014

BMJ Open

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ABSTRACT

Objective We aimed to explore the association between periodontitis and abdominal aortic calcification (AAC) among a nationally representative sample of US adults. Design Cross- sectional study. Setting The National Health and Nutrition Examination Survey (2013–2014). Participants A total of 2149 participants aged 40 years or older who have complete information for periodontitis and AAC assessment test were included in this study. Primary and secondary outcome measures AAC scores can be accurately identified on lateral spine images obtained by dual-energy X-ray absorptiometry, and both the AAC-24 and AAC-8 semiquantitative scoring tools were used for AAC evaluation. Linear regression analysis was used to investigate the relationship between periodontitis and the AAC-8 and AAC-24 scores. Multivariate logistic regression models and reported ORs were used to examine the relationship between periodontitis and AAC. Results The prevalence of severe periodontitis combined with severe AAC was 8.49%–8.54%. According to the AAC-8 and AAC-24 score classifications, patients with severe periodontitis had higher odds of severe AAC (AAC-8 score ≥3: (OR: 2.53; 95% CI 1.04 to 6.17) and AAC-24 score >6: (OR: 3.60; 95% CI 1.48 to 8.78)). A positive association between mild–moderate periodontitis and severe AAC was found only when the AAC-24 score was applied (OR: 2.25; 95% CI 1.24 to 4.06). In the subgroup analyses, the likelihood ratio test showed no multiplicative interaction (all p value for interaction >0.05). Conclusions The findings showed that periodontitis is associated with an increased risk of severe AAC in the US population aged 40 years and older; this requires further large-scale prospective studies for confirmation.

CITATION EXPORT

Kaisaierjiang Kadier, Anniwaer Abulizi, Aikeliyaer Ainiwaer et al.. Unravelling the link between periodontitis and abdominal aortic calcification in the US adult population: a cross-sectional study based on the NHANES 2013–2014. BMJ Open. (2023). https://doi.org/10.1136/bmjopen-2022-068931

AUTHORS

6 · 1 CENTRES

Kaisaierjiang Kadier, Anniwaer Abulizi, Aikeliyaer Ainiwaer, Rena Rehemuding, Xiang Ma, Yi-Tong Ma

Heart Center, Xinjiang Medical University Affiliated First Hospital, Urumqi, China