Immunity, Inflammation and Disease · 5 authors, 1 centre
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This cross-sectional study compared tear fluid from 58 hyperuricemia/gout patients and 58 healthy controls, finding that patients had higher tear uric acid and interleukin-1β levels. Tear uric acid was independently associated with tear interleukin-1β concentration.
This cross-sectional study analyzed tear and serum samples from 58 patients with hyperuricemia (including 40 asymptomatic and 18 with gout) and 58 healthy controls. Tear uric acid levels were significantly higher in the hyperuricemia group (98.2 ± 51.5 µmol/L) compared to controls (42.7 ± 24.0 µmol/L). Tear interleukin-1β (IL-1β) concentrations were also significantly higher in hyperuricemia patients (210.2 ± 113.9 pg/mL) than in controls (142.6 ± 29.8 pg/mL). A multiple linear regression analysis showed a significant, independent positive association between tear uric acid levels and tear IL-1β concentrations. No significant correlations were found for tumor necrosis factor-alpha (TNF-α). There were no statistically significant differences in tear IL-1β or TNF-α levels between the asymptomatic hyperuricemia and gout subgroups. Limitations include a small sample size, a cross-sectional design that cannot assess changes over time, and the lack of direct clinical data on ocular manifestations. The findings suggest an interaction between hyperuricemia and ocular inflammation mediated by IL-1β.
