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TL;DR
This preclinical study tested the gastroprotective effect of Callistemon citrinus leaf extract in obese rats with experimentally induced gastric ulcers. The extract reduced ulcer severity and decreased inflammatory markers.
PeerJ · 7 authors, 3 centres
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This preclinical study tested the gastroprotective effect of Callistemon citrinus leaf extract in obese rats with experimentally induced gastric ulcers. The extract reduced ulcer severity and decreased inflammatory markers.
The study evaluated the gastroprotective effect of ethanolic Callistemon citrinus leaf extract (250 mg/kg) in obese female Wistar rats. Obesity was induced with a high-fat-sugar diet for 15 weeks, and gastric ulcers were subsequently induced with a single oral dose of indomethacin (30 mg/kg). The extract, administered daily during the obesity induction period, significantly reduced the severity of gastric lesions. This reduction was associated with decreased activity of inflammatory enzymes (myeloperoxidase, cyclooxygenase-2, 5-lipoxygenase) and lower levels of pro-inflammatory cytokines (TNFα, IL-6). The extract also decreased weight gain and other morphological and biochemical parameters.