SEARCHCOHORTpediatrics, obstetrics and gynecology

cohort·pediatrics, obstetrics and gynecology, endocrinology, epidemiology, public health·PMC10517447

Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls

Environment international · 7 authors, 6 centres

AI SUMMARY

FIDELITY 100%

POPULATIONCohort of 366 Chilean adolescent girls from the Growth and Obesity Cohort Study.

INTERVENTIONMeasurement of urinary concentrations of 15 suspected EDC biomarkers (phthalates, phenols, parabens) at three pubertal time points: Tanner breast stage 1 (B1), stage 4 (B4), and 1-year post-menarche.

COMPARISONComparison of EDC biomarker concentrations across pubertal time points; associations were evaluated between EDC levels at each time point and breast outcomes at 2-years post-menarche.

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AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

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TL;DR

This longitudinal cohort study of Chilean girls measured urinary endocrine disrupting chemical (EDC) biomarkers at three pubertal stages and found that concentrations were highly variable over time, with select EDCs measured at specific stages associated with adolescent breast density and volume measured post-menarche.

Full summary

965 CHARS

In a longitudinal cohort of 366 Chilean girls, urinary concentrations of 15 endocrine disrupting chemical (EDC) biomarkers were measured at three pubertal stages (Tanner breast stage B1, B4, and 1-year post-menarche) to assess variability and association with adolescent breast composition at 2-years post-menarche. EDC biomarker concentrations showed high variability across time points (ICC range 0.01–0.30), with concentrations for 12 biomarkers decreasing over time. Linear mixed models and generalized estimating equations were used, adjusted for age, body fat percentage, total caloric intake, and maternal education. Triclosan at 1-year post-menarche was inversely associated with %FGV. No parabens were associated with outcomes. The study suggests potential pubertal windows of susceptibility for certain EDCs, but findings may be due to chance given multiple testing. Limitations include potential exposure misclassification from single spot urine samples.

PICO

PPOPULATION

Cohort of 366 Chilean adolescent girls from the Growth and Obesity Cohort Study.

IINTERVENTION

Measurement of urinary concentrations of 15 suspected EDC biomarkers (phthalates, phenols, parabens) at three pubertal time points: Tanner breast stage 1 (B1), stage 4 (B4), and 1-year post-menarche.

OOUTCOME

Breast fibroglandular volume (%FGV and aFGV) and total breast volume (tBV) at 2-years post-menarche.

STUDY TYPE

cohort

SPECIALTY

pediatrics

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10517447

Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls

Environment international

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ABSTRACT

Background: Epidemiologic evidence suggests that environmental factors acting as endocrine disrupting chemicals (EDCs) are associated with mammographic breast density and the risk of breast cancer. Exposure to EDCs during puberty, a period of rapid breast development, may affect susceptibility to breast carcinogenesis. Methods: In a cohort of 366 Chilean adolescents from the Growth and Obesity Cohort Study, we evaluated the relation between urinary concentrations of 15 suspected EDC biomarkers across three pubertal time points (Tanner breast stage 1 (B1), 4 (B4), and 1-year post-menarche) and breast fibroglandular volume (FGV; percent FGV [%FGV] and absolute FGV [aFGV]) and total breast volume (tBV) at 2-years post-menarche. We used linear mixed models to test differences in creatinine-corrected EDC biomarker concentrations at B4 and 1-year post-menarche compared to B1 and calculated intraclass correlation coefficients (ICC) of EDC concentrations across time points to appraise the consistency of measurements. We fit multivariable generalized estimating equations (GEEs) to evaluate windows of susceptibility for the association between log 10 -transformed EDCs and log 10 -transformed breast outcomes. GEEs were adjusted for age, body fat percentage, total caloric intake, and maternal education. Results: Urinary EDC biomarker concentrations highly varied across pubertal time points (ICC range 0.01–0.30). For 12 EDCs, biomarker concentrations decreased over time. Triclosan measured at 1-year post-menarche was inversely associated with %FGV at 2-years post-menarche (β = −0.025, 95 % confidence interval = −0.041, −0.008). Mono(2-ethyl-5-carboxypentyl) phthalate and the sum of di(2-ethylhexyl) phthalate metabolite concentrations at B4 were positively associated with aFGV and tBV at 2-years post-menarche. No measured phenols were associated with aFGV and tBV, while no measured parabens were associated with %FGV and aFGV. Conclusions: Our study suggests relatively high variability in EDC biomarker concentrations across the peripubertal time period. We also found evidence to suggest that there may be pubertal windows of susceptibility to select EDCs for the association with adolescent breast density.

CITATION EXPORT

Lara S. Yoon, Alexandra M. Binder, Ana Pereira et al.. Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls. Environment international. (2022). https://doi.org/10.1016/j.envint.2022.107586

AUTHORS

7 · 6 CENTRES

Lara S. Yoon, Alexandra M. Binder, Ana Pereira, Antonia M. Calafat, John Shepherd, Camila Corvalán, Karin B. Michels

aDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, 650 Charles E. Young Drive South, Los Angeles, CA 90025, USA
bCancer Epidemiology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA
cInstitute of Nutrition and Food Technology, University of Chile, Macul, Santiago 7830490, Chile
dDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F17, Atlanta, GA 30341, USA
ePopulation Sciences in the Pacific Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA
fInstitute for Prevention and Cancer Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Elsässerstraße 2, 79110 Freiburg, Germany