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other·preclinical research, biomedical research, nutrition, micronutrients, vitamins·PMC10521393

Vitamin D 3 supplementation improves spatial memory, muscle function, pain score, and modulates different functional physiological biomarkers in vitamin D 3 deficiency diet (VDD)-induced rats model

BMC Nutrition · 5 authors, 2 centres

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This study used a rat model to investigate the effects of chronic vitamin D3 supplementation on deficits induced by a vitamin D3-deficient diet (VDD).

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This study used a rat model to investigate the effects of chronic vitamin D3 supplementation on deficits induced by a vitamin D3-deficient diet (VDD). Rats on the VDD showed impaired spatial memory (reduced entries/time in novel Y-maze arm), decreased muscle grip strength, and altered pain scores. Vitamin D3 supplementation for 56 days significantly improved these behavioral outcomes. The supplementation also significantly increased vitamin D receptor (VDR) expression in liver and serum 25-OH vitamin D3 levels. Biomarker analysis showed supplementation reduced parathyroid hormone (PTH) by 32.5% and C-reactive protein (CRP) by 35.27%, while increasing calcitonin by 36.67%. In cerebrospinal fluid, levels of klotho and β-endorphin were elevated by 19.67% and 133.59%, respectively, compared to the VDD group. The findings suggest a potential role for vitamin D in managing deficiencies and associated cognitive or muscular impairments.

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other

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preclinical research

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ORIGINAL PAPER

PMC10521393

Vitamin D 3 supplementation improves spatial memory, muscle function, pain score, and modulates different functional physiological biomarkers in vitamin D 3 deficiency diet (VDD)-induced rats model

BMC Nutrition

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ABSTRACT

Abstract Background Vitamin D Deficiency is recognized as a pandemic, which is associated with high mortality. An inadequate level of vitamin D is associated with autoimmune diseases, hypertension, and cancer. The study was aimed to assess the pharmacological effects of chronic vitamin D 3 supplementation on the manipulation diet regiment of deprived cholecalciferol (vitamin D 3 deficient diet, VDD) rats. Methods Memory performance (Y-maze task), muscular function (muscle grip strength), and pain score (pressure application measurement meter) were measured. Functional biomarkers were measured using ELISA method in different matrix viz. in serum (parathyroid hormone; PTH, calcitonin, thyroxine, and C-reactive protein; CRP, 25-OH Vit D 3 ), and in CSF (klotho and β-endorphin). 25-OH Vit D 3 was also estimated in liver and kidney homogenate using ELISA. Vitamin D receptor (VDR) was measured spectrophotometrically in liver and adipose tissue. Results VDD-induced rats showed a decrease in number of entries and time spent in the novel arm and spontaneous alternations in the Y-maze task. Significant improvements of neuromuscular function and pain score after addition of vitamin D 3 . In comparison to the VDD group, VDR expression (liver) and active metabolites of vitamin D 3 (25-OH vit.D 3 ) in serum were significantly higher by 48.23% and 280%, respectively. The PTH and CRP levels were significantly reduced by 32.5% and 35.27%, respectively, whereas calcitonin was increased by 36.67% compared with the VDD group. Klotho and β-endorphin expressions in cerebrospinal fluid were significantly elevated by 19.67% and 133.59%, respectively, compared to VDD group. Conclusions Overall, the results indicate that supplementation of cholecalciferol significantly improved spatial memory impairment, VDR expression, and may provide an opportunity to manage vitamin D deficiencies. Keywords: Cholecalciferol, Vitamin d 3 deficiency diet, klotho, VDR, Spatial memory

CITATION EXPORT

Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi et al.. Vitamin D3 supplementation improves spatial memory, muscle function, pain score, and modulates different functional physiological biomarkers in vitamin D3 deficiency diet (VDD)-induced rats model. BMC Nutrition. (2023). https://doi.org/10.1186/s40795-023-00767-0

AUTHORS

5 · 2 CENTRES

Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Sambhu Mondal, Snehasis Jana

1Trivedi Global, Inc, Henderson, NV USA
2Trivedi Science Research Laboratory Pvt. Ltd, Thane (W), Maharashtra India