SEARCHSYSTEMATIC_REVIEWhematology, oncology

systematic_review·hematology, oncology, nutrition, systematic review, micronutrients·PMC10047650

Vitamin D and Multiple Myeloma: A Scoping Review

Current Oncology · 4 authors, 5 centres

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FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

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TL;DR

This scoping review mapped 15 human studies on vitamin D and multiple myeloma.

Full summary

954 CHARS

This scoping review, guided by PRISMA-ScR procedures, identified and mapped 15 peer-reviewed human studies on vitamin D and multiple myeloma (MM). The synthesis reveals that vitamin D deficiency is prevalent among MM patients, with 42.3% of participants in the reviewed studies identified as deficient. The review found no publications reporting on vitamin D status and the risk of developing MM. Evidence for associations with prognosis was mixed: two of three survival studies reported an association between deficiency and poorer outcomes, while findings on MM stage, peripheral neuropathy, and bony disease were conflicting. VDR polymorphisms were also noted as a research area. Limitations include the hypothesis-generating nature of scoping reviews, the absence of grey literature, and a non-registered protocol. The review identifies knowledge gaps, such as the need for research on vitamin D and MM risk, and suggests future experimental studies.

STUDY TYPE

systematic_review

SPECIALTY

hematology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10047650

Vitamin D and Multiple Myeloma: A Scoping Review

Current Oncology

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ABSTRACT

As the global incidence of multiple myeloma (MM) increases, the identification of modifiable risk factors for disease prevention becomes paramount. Maintaining optimal vitamin D status is a candidate for prevention efforts, based on pre-clinical evidence of a possible role in disease activity and progression. A structured scoping review was performed to identify and describe human-level research regarding the association between vitamin D and MM risk and/or prognosis. Searches of three databases (OVID-Medline, OVID-Embase, and OVID-Cochrane Library) yielded 15 included publications. Vitamin D deficiency is fairly common among patients with MM, with 42.3% of participants in the studies identified as having a vitamin D deficiency. No included publication reported on vitamin D status and the risk of developing or being newly diagnosed with MM. Possible associations with vitamin D that warrant future exploration include the incident staging of MM disease, the occurrence of peripheral neuropathy, and survival/prognosis. Vitamin D receptor (VDR) polymorphisms associated with MM also warrant further investigation. Overall, this scoping review was effective in mapping the research regarding vitamin D and MM and may help support new hypotheses to better describe this association and to better address identified knowledge gaps in the literature.

CITATION EXPORT

Naghmeh Mirhosseini, Athanasios Psihogios, Meagan D. McLaren et al.. Vitamin D and Multiple Myeloma: A Scoping Review. Current Oncology. (2023). https://doi.org/10.3390/curroncol30030248

AUTHORS

4 · 5 CENTRES

Naghmeh Mirhosseini, Athanasios Psihogios, Meagan D. McLaren, Dugald Seely

1The Patterson Institute for Integrative Oncology Research, Toronto, ON M2K 1E2, Canada
2Kingston Integrative Healthcare Center (KIHC), Kingston, ON K7L 4T6, Canada
3School of Public Health, University of Saskatchewan, Saskatoon, SK S7N 2Z4, Canada
4The Centre for Health Innovation, Ottawa, ON K2P 0M7, Canada
5Ottawa Hospital Research Institute, Ottawa, ON K1Y 4E9, Canada